Acquired Aplastic Anemia
Acquired Aplastic Anemia Robert A. Brodsky HISTORICAL BACKGROUND The earliest case description of aplastic anemia was by Dr. Paul Ehrlich in 1888.1 He described a young woman who died following…
Megaloblastic Anemias:Disorders of Impaired Dna Synthesis
Megaloblastic Anemias:Disorders of Impaired Dna Synthesis Ralph Carmel HISTORICAL BACKGROUND The story of megaloblastic anemia, its causes, and how they were decoded is a wonderfully instructive chapter of medicine. Clinical…
Thalassemias and Related Disorders: Quantitative Disorders of Hemoglobin Synthesis
Thalassemias and Related Disorders: Quantitative Disorders of Hemoglobin Synthesis Caterina Borgna-Pignatti Renzo Galanello* Dedication: We wish to dedicate this chapter to Rino Vullo and Antonio Cao who passed away on…
Hemoglobins with Altered Oxygen Affinity, Unstable Hemoglobins, M-Hemoglobins, and Dyshemoglobinemias
Hemoglobins with Altered Oxygen Affinity, Unstable Hemoglobins, M-Hemoglobins, and Dyshemoglobinemias Martin H. Steinberg More than 1,100 mutations affecting the globin subunits of hemoglobin have been described (http://globin.cse.psu.edu/), and among these,…
Sickle Cell Anemia and Other Sickling Syndromes
Sickle Cell Anemia and Other Sickling Syndromes Jane S. Hankins Winfred C. Wang This chapter discusses hemoglobin (Hb) variants that cause alterations in erythrocyte morphology and rheology. Hb S, or…
Acquired Nonimmune Hemolytic Disorders
Acquired Nonimmune Hemolytic Disorders Robert T. Means, Jr. Bertil Glader Hemolysis occurs when red blood cells (RBCs) are exposed to a variety of infectious agents, chemicals, or physical stresses. In…
Paroxysmal Nocturnal Hemoglobinuria
Paroxysmal Nocturnal Hemoglobinuria Charles J. Parker Russell E. Ware INTRODUCTION Definition Although usually classified as a hemolytic anemia, paroxysmal nocturnal hemoglobinuria (PNH) is a disease of the hematopoietic stem cell….
Hemolytic Disease of the Fetus and Newborn
Hemolytic Disease of the Fetus and Newborn Charles T. Quinn Anne F. Eder Catherine S. Manno Hemolytic disease of the fetus and newborn (HDFN) results from the destruction of red…
Autoimmune Hemolytic Anemia
Autoimmune Hemolytic Anemia Richard C. Friedberg Vandita P. Johari CLASSIFICATION In autoimmune hemolytic anemia (AIHA), pathologic antibodies (autoantibodies) attach to and lead to the destruction (hemolysis) of endogenous erythrocytes (red…
Hereditary Hemolytic Anemias Due to Red Blood Cell Enzyme Disorders
Hereditary Hemolytic Anemias Due to Red Blood Cell Enzyme Disorders Bertil Glader OVERVIEW OF ERYTHROCYTE METABOLISM Mature red blood cells (RBCs) are anucleate (thereby incapable of cell division), devoid of…
