Plasma Cell Disorders

Nov 20, 2018 by in HEMATOLOGY Comments Off on Plasma Cell Disorders

Plasma Cell Disorders Tomer M. Mark, MD Geraldine P. Schechter, MD, MACP Plasma cells are terminally differentiated B cells responsible for immunoglobulin production. Plasma cell disorders represent a group of…

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Lymphoproliferative Disorders

Nov 20, 2018 by in HEMATOLOGY Comments Off on Lymphoproliferative Disorders

Lymphoproliferative Disorders Elizabeth Margolskee, MD, MPH Peter Martin, MD The diagnosis and classification of lymphoid tumors is a multistep process involving integration of clinical, morphologic, phenotypic, and molecular data. The…

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Myeloproliferative Neoplasms

Nov 20, 2018 by in HEMATOLOGY Comments Off on Myeloproliferative Neoplasms

Myeloproliferative Neoplasms Olga Pozdnyakova, MD, PhD Attilio Orazi, MD Myeloproliferative neoplasms (MPNs) are a group of clonal disorders of the hematopoietic stem cells that share similar features, such as hypercellular…

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Acute Leukemias

Nov 20, 2018 by in HEMATOLOGY Comments Off on Acute Leukemias

Acute Leukemias Julia T. Geyer, MD Sangmin Lee, MD Acute leukemias are hematologic malignancies characterized by increased numbers of myeloid or lymphoid blasts. The term “acute,” historically referring to a…

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Myelodysplastic Syndromes

Nov 20, 2018 by in HEMATOLOGY Comments Off on Myelodysplastic Syndromes

Myelodysplastic Syndromes Olga Pozdnyakova, MD, PhD Robert P. Hasserjian, MD The myelodysplastic syndromes (MDSs) are a heterogeneous group of disorders caused by a clonal expansion of hematopoietic stem cells in…

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Hemostasis and Platelet Disorders

Nov 20, 2018 by in HEMATOLOGY Comments Off on Hemostasis and Platelet Disorders

Hemostasis and Platelet Disorders Marcia Paddock, MD, PhD John V. Mitsios, PhD Maria T. DeSancho, MD, MSc HEMOSTASIS AND ITS ROLE IN DISEASE Hemostasis Hemostasis is the process by which…

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Anemia

Nov 20, 2018 by in HEMATOLOGY Comments Off on Anemia

Anemia Joshua A. Hayden, PhD Babette B. Weksler, MD The criteria for anemia depend upon age, gender, ethnicity, and pregnancy status. The World Health Organization (WHO) has defined anemia as…

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Techniques for Assessing Blood Disorders: Flow Cytometry, Multiplex Immunohistochemistry, Karyotyping, FISH, and Molecular Approaches

Nov 20, 2018 by in HEMATOLOGY Comments Off on Techniques for Assessing Blood Disorders: Flow Cytometry, Multiplex Immunohistochemistry, Karyotyping, FISH, and Molecular Approaches

Techniques for Assessing Blood Disorders: Flow Cytometry, Multiplex Immunohistochemistry, Karyotyping, FISH, and Molecular Approaches Scott A. Ely, MD, MPH New techniques, platforms, and companies spring into view on a regular…

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