Molecular Targets and Pathways

Sep 29, 2018 by in ONCOLOGY Comments Off on Molecular Targets and Pathways

Molecular Targets and Pathways Technological advances have paved the way for a precision treatment tailored to both patient and tumor. DNA is the key to targeted anti-cancer therapies. We want…

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Targeted and Immunotherapy Agents

Sep 29, 2018 by in ONCOLOGY Comments Off on Targeted and Immunotherapy Agents

Targeted and Immunotherapy Agents Color Key Agents in early-stage clinical trial investigations first in man, phase 1 Agents in late-stage clinical trial investigations (phases 2 and 3) FDA-approved agents FDA-approved…

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Palliation

Sep 29, 2018 by in ONCOLOGY Comments Off on Palliation

Palliation INTRODUCTION Radiation therapy (RT) can be a highly effective tool for the treatment of symptoms caused by progressive gynecologic cancers. Common indications for palliative treatment of gynecologic cancers include…

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Unknown Primary

Sep 29, 2018 by in ONCOLOGY Comments Off on Unknown Primary

Unknown Primary INTRODUCTION Most gynecologic cancers present with bleeding, pain, or other symptoms caused by an enlarging primary tumor. However, in some cases, patients are initially diagnosed when lymphadenopathy or…

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Ovarian Cancer

Sep 29, 2018 by in ONCOLOGY Comments Off on Ovarian Cancer

Ovarian Cancer INTRODUCTION As will be shown later in this chapter, there is strong evidence that radiation therapy (RT) can play an important role in the curative treatment of selected…

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Targets by Organ Site

Sep 29, 2018 by in ONCOLOGY Comments Off on Targets by Organ Site

Targets by Organ Site Abbreviations • CBR: clinical benefit rate (CR + PR + SD) • CR: complete response • d: days • DOR: duration of response • HR: heart…

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Vulvar Cancer

Sep 29, 2018 by in ONCOLOGY Comments Off on Vulvar Cancer

Vulvar Cancer Before the mid-1980s, it was commonly believed that radiation therapy (RT) had no role in the curative management of vulvar cancer. Then in 1986, Homesley et al.1 reported…

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Uterine Cancer

Sep 29, 2018 by in ONCOLOGY Comments Off on Uterine Cancer

Uterine Cancer INTRODUCTION Most endometrial cancers are cured by simple removal of the uterus. For this reason, investigators have tended to focus their attention on improving methods of identifying the…

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Vaginal Cancer

Sep 29, 2018 by in ONCOLOGY Comments Off on Vaginal Cancer

Vaginal Cancer INTRODUCTION Among the gynecologic malignancies treated with radiation therapy, vaginal cancers pose some of the greatest management challenges. Several factors contribute to this: Vaginal cancer is rare. Fewer…

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