HEMATOLOGY

Polyclonal Polycythemias (Primary and Secondary)

Jan 8, 2019 by in HEMATOLOGY Comments Off on Polyclonal Polycythemias (Primary and Secondary)

INTRODUCTION Polycythemia, also referred to as erythrocytosis, is characterized by an increased red cell mass. There is no consensus on terminology (ie, primary familial polycythemia but postrenal transplantation erythrocytosis). Polycythemias…

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Fragmentation Hemolytic Anemia

Jan 8, 2019 by in HEMATOLOGY Comments Off on Fragmentation Hemolytic Anemia

DEFINITION Acquired erythrocyte fragmentation occurs when red cells are forced at high shear stress through partial vascular occlusions or over abnormal vascular surfaces. In circumstances in which fragmentation of red…

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Drug-Induced Hemolytic Anemia

Jan 8, 2019 by in HEMATOLOGY Comments Off on Drug-Induced Hemolytic Anemia

ETIOLOGY AND PATHOGENESIS Three mechanisms of drug-related immunologic injury to red cells are defined: — Hapten/drug adsorption involving drug-dependent antibodies — Ternary complex formation involving drug-dependent antibodies — Induction of…

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Hemolytic Anemia Resulting from Infectious Agents

Jan 8, 2019 by in HEMATOLOGY Comments Off on Hemolytic Anemia Resulting from Infectious Agents

INTRODUCTION Hemolysis represents a prominent part of the overall clinical picture in many infections. Table 21–1 lists the microorganisms associated with the induction of hemolytic anemia. TABLE 21–1ORGANISMS THAT CAUSE…

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Hypersplenism and Hyposplenism

Jan 8, 2019 by in HEMATOLOGY Comments Off on Hypersplenism and Hyposplenism

THE SPLEEN The white pulp (lymphoid tissue) functions in antigen processing and antibody production. The red pulp (monocyte-macrophage system) serves as a filter, retaining defective blood cells and foreign particles….

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Plasma Cell Disorders

Nov 20, 2018 by in HEMATOLOGY Comments Off on Plasma Cell Disorders

Plasma Cell Disorders Tomer M. Mark, MD Geraldine P. Schechter, MD, MACP Plasma cells are terminally differentiated B cells responsible for immunoglobulin production. Plasma cell disorders represent a group of…

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Lymphoproliferative Disorders

Nov 20, 2018 by in HEMATOLOGY Comments Off on Lymphoproliferative Disorders

Lymphoproliferative Disorders Elizabeth Margolskee, MD, MPH Peter Martin, MD The diagnosis and classification of lymphoid tumors is a multistep process involving integration of clinical, morphologic, phenotypic, and molecular data. The…

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Myeloproliferative Neoplasms

Nov 20, 2018 by in HEMATOLOGY Comments Off on Myeloproliferative Neoplasms

Myeloproliferative Neoplasms Olga Pozdnyakova, MD, PhD Attilio Orazi, MD Myeloproliferative neoplasms (MPNs) are a group of clonal disorders of the hematopoietic stem cells that share similar features, such as hypercellular…

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Acute Leukemias

Nov 20, 2018 by in HEMATOLOGY Comments Off on Acute Leukemias

Acute Leukemias Julia T. Geyer, MD Sangmin Lee, MD Acute leukemias are hematologic malignancies characterized by increased numbers of myeloid or lymphoid blasts. The term “acute,” historically referring to a…

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Myelodysplastic Syndromes

Nov 20, 2018 by in HEMATOLOGY Comments Off on Myelodysplastic Syndromes

Myelodysplastic Syndromes Olga Pozdnyakova, MD, PhD Robert P. Hasserjian, MD The myelodysplastic syndromes (MDSs) are a heterogeneous group of disorders caused by a clonal expansion of hematopoietic stem cells in…

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