HEMATOLOGY

Chapter 12 – Systemic Mastocytosis

Jan 4, 2021 by in HEMATOLOGY Comments Off on Chapter 12 – Systemic Mastocytosis

Abstract Mastocytosis is a diverse group of rare diseases due to a clonal proliferation of neoplastic mast cells that can involve a wide variety of organ systems. The two main…

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Chapter 15 – Mature Lymphoid Neoplasms

Jan 4, 2021 by in HEMATOLOGY Comments Off on Chapter 15 – Mature Lymphoid Neoplasms

Abstract The classification of mature neoplasms has evolved over the years, with the current WHO classification based largely on the genetics and cellular origin of lymphoid neoplasms [1]. Clinical behaviour…

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Chapter 16 – Plasma Cell Neoplasia

Jan 4, 2021 by in HEMATOLOGY Comments Off on Chapter 16 – Plasma Cell Neoplasia

Abstract Plasma cell neoplasms are derived from mature, IG heavy chain class-switched terminally differentiated B-cells, which usually secrete a monoclonal immunoglobulin or M-protein and consist of a homogeneous population of…

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Chapter 17 – Metastatic Lesions

Jan 4, 2021 by in HEMATOLOGY Comments Off on Chapter 17 – Metastatic Lesions

Abstract The bone marrow (BM) is a frequent site of haematogenous spread for all types of cancer. Metastatic spread of disseminated tumour cells (DTCs) to the BM is detected in…

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Chapter 14 – Precursor Lymphoid Neoplasms

Jan 4, 2021 by in HEMATOLOGY Comments Off on Chapter 14 – Precursor Lymphoid Neoplasms

Abstract Neoplasms arising from precursor lymphoid cells committed to the B-cell or T-cell lineage can present primarily in the bone marrow (BM), blood (i.e. leukaemic presentation) or at extramedullary tissue…

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