Mogamulizumab in Adult T-Cell Leukemia/Lymphoma

Jul 27, 2017 by in ONCOLOGY Comments Off on Mogamulizumab in Adult T-Cell Leukemia/Lymphoma

Fig. 9.1 CC chemokine receptor 4 (CCR4) and humanized anti-CCR4 monoclonal antibody, KW-0761. The CCR4 gene is located on chromosome 3p24. CCR4 is a seven-domain transmembrane G protein-coupled receptor, and…

read more

Imatinib: Basic Results

Jul 27, 2017 by in ONCOLOGY Comments Off on Imatinib: Basic Results

Fig. 2.1 Timeline of BCR-ABL findings and development of imatinib 2.2 Molecular Biology of CML 2.2.1 Ph Chromosome The Ph chromosome results from a reciprocal translocation, which involves the BCR…

read more

Imatinib: Clinical Pharmacology and Therapeutic Results

Jul 27, 2017 by in ONCOLOGY Comments Off on Imatinib: Clinical Pharmacology and Therapeutic Results

Response Definitions Hematologic response (HR)  Complete hematologic response (CHR) WBC <10 × 109/L Platelet count <450 × 109/L Basophil <5% No immature cells Spleen nonpalpable Cytogenetic response (CyR)  Complete cytogenetic…

read more

FLT3 Inhibitors

Jul 27, 2017 by in ONCOLOGY Comments Off on FLT3 Inhibitors

Fig. 10.1 Type I and type II FLT3 inhibitors. The binding of FL to the extracellular domain of wild-type FLT3 leads to its dimerization, stabilizing a conformation in an active…

read more

Forodesine

Jul 27, 2017 by in ONCOLOGY Comments Off on Forodesine

Fig. 15.1 Metabolism of purine nucleotides 15.2 Forodesine Forodesine [BCX-1777, immucillin-H, 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-hydroxymethyl-2-pyrrolidinyl]-1,5-dihydro-4H-pyrrolo-[3,2-d]-pyrimidin-4-one, monohydrochloride] is a transition-state analog that potently inhibits PNP enzyme activity (Fig. 15.2) [12–15]. Forodesine has shown anticancer…

read more
Get Clinical Tree app for offline access