ENDOCRINOLOGY

Triggers Causing Type 1 Diabetes

Apr 14, 2017 by in ENDOCRINOLOGY Comments Off on Triggers Causing Type 1 Diabetes

Fig. 2.1 Detailed genetic composition on human MHC (HLA) including type 1 diabetes risk Fig. 2.2 Communication and interaction pathways between an APC and T-cell. APC presents a processed antigen peptide via…

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Introduction to Diabetes and Type 1 Diabetes

Apr 14, 2017 by in ENDOCRINOLOGY Comments Off on Introduction to Diabetes and Type 1 Diabetes

Classification of diabetes Type 1 diabetes (T1D) Type 2 diabetes (T2D) Gestational diabetes Synonym IDDM, juvenile-onset diabetes NIDDM, adult-onset diabetes GDM Epidemiology 5–10 % of total cases 90–95 % of total cases…

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Balance, Obesity and Type-2 Diabetes

Apr 14, 2017 by in ENDOCRINOLOGY Comments Off on Balance, Obesity and Type-2 Diabetes

Energy Balance Whether the net energy balance of an adult animal is positive or negative will depend upon energy intake versus energy expenditure as illustrated below (in growing animals another…

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Manipulation of Mouse Metabolism.

Apr 14, 2017 by in ENDOCRINOLOGY Comments Off on Manipulation of Mouse Metabolism.

In a typical experiment, animals of different genotypes or in different experimental conditions are challenged with one or more experimental diets, and their biological responses under these diets are compared…

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of Overeating

Apr 14, 2017 by in ENDOCRINOLOGY Comments Off on of Overeating

Figure 1 Decreased activation in the caudate in response to milkshake receipt (contrasted with tasteless receipt) by weight change group over a 6-month period. Those that gained weight (solid line)…

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Models of Obesity (DIO) in Rodents

Apr 14, 2017 by in ENDOCRINOLOGY Comments Off on Models of Obesity (DIO) in Rodents

Materials Adult male inbred mice, e.g., C57Bl6 (see Critical Parameters for considerations of age and group size) 60% Kcal fat, purified diet (Research Diets Inc., Harlan Teklad, Dyets Inc., Bio-Serv,…

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