ONCOLOGY

The clinical application of immuno-therapeutics

Aug 6, 2023 by in ONCOLOGY Comments Off on The clinical application of immuno-therapeutics

Summary of key facts • Immuno-oncology (IO) is one of the fastest-growing therapeutic areas within oncology. • IO agents work indirectly via the host’s adaptive and innate immune systems to…

read more

The microbiome and cancer immunotherapy

Aug 6, 2023 by in ONCOLOGY Comments Off on The microbiome and cancer immunotherapy

Summary of key facts • The human microbiota is composed of bacteria, viruses, fungi, yeast, protozoa, and archaea. Because of its commensal relationship with the host, it is identified as…

read more

Vaccines and active immunization against cancer

Aug 6, 2023 by in ONCOLOGY Comments Off on Vaccines and active immunization against cancer

Summary of key facts • Cancer vaccines represent a promising strategy to activate immunity in cold tumors. • The complexity and heterogeneity of human tumors remains a challenge to developing…

read more

Tumor immune surveillance

Aug 6, 2023 by in ONCOLOGY Comments Off on Tumor immune surveillance

Summary of key facts • The concept of tumor immunosurveillance can be traced back to the early 1900s in association with observations that a potentially overwhelming frequency of carcinomas must…

read more

Cancer—avoiding immune detection

Aug 6, 2023 by in ONCOLOGY Comments Off on Cancer—avoiding immune detection

Summary of key facts • The natural history of a human malignancy and its relationship to the host immune system has been described as comprising the “three Es”: elimination, equilibrium,…

read more

Tumor antigenicity and cancer as non-self

Aug 6, 2023 by in ONCOLOGY Comments Off on Tumor antigenicity and cancer as non-self

Summary of key facts • Professor Paul Ehrlich is credited with introducing the concept of cancers as non-self and proposing the concept of tumor immune surveillance in 1909. • Evidence…

read more

Cancer and the science of innate immunity

Aug 6, 2023 by in ONCOLOGY Comments Off on Cancer and the science of innate immunity

Summary of key facts • The innate immune system is the host’s first line of immune defense against challenges of the environment. • The innate immune system response is a…

read more
Get Clinical Tree app for offline access