ONCOLOGY

Molecular Mechanisms in Non-Hodgkin Lymphoma

Sep 20, 2017 by in ONCOLOGY Comments Off on Molecular Mechanisms in Non-Hodgkin Lymphoma

(1) Department of Patholog, University of Massachusetts Medical School, Baystate, Springfield, MA, USA (2) Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC,…

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Molecular Biology of Leukemias

Sep 20, 2017 by in ONCOLOGY Comments Off on Molecular Biology of Leukemias

Chromosomal translocations Genes Comments Involving RARAα t(15;17)(q21;q21) PML DNA binding, cell proliferation RARα Transcription factor t(11;17)(q23;q21) ZBTB16 (PLZF) Zn-finger transcription factor RARα Transcription factor t(5;17)(q32;q21) NPM1 RNA transport/processing RARα Transcription…

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Small Molecule Inhibitors

Sep 20, 2017 by in ONCOLOGY Comments Off on Small Molecule Inhibitors

Fig. 40.1 Discovery of imatinib . Binding of imatinib occurs at the ATP-binding site as indicated by docking studies [28] and X-ray crystallography [29]. It has also been shown from…

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Simple Sequence Mutations

Sep 20, 2017 by in ONCOLOGY Comments Off on Simple Sequence Mutations

Fig. 13.1 Genetic heterogeneity of cancer cells. All cancer cells are derived from a common ancestor cell (black dot) that was subject to the pathogenic mutation (w). After an initial…

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Molecular Biology of Human Brain Tumors

Sep 20, 2017 by in ONCOLOGY Comments Off on Molecular Biology of Human Brain Tumors

Fig. 35.1 MRI sequences of common primary brain tumors. (a) Sagittal T1-weighted and gadolinium-enhanced MR image showing a medulloblastoma in the posterior fossa (arrow) with compression of the pons and…

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Cancer Genomics

Sep 20, 2017 by in ONCOLOGY Comments Off on Cancer Genomics

Fig. 3.1 Expression profiling schema. Above, schematic depiction of two-color hybridization on cDNA or oligonucleotide microarrays. RNA isolated from test and reference samples is labeled with two different fluors (here…

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Hereditary Cancer

Sep 20, 2017 by in ONCOLOGY Comments Off on Hereditary Cancer

Fig. 22.1 Aldred Scott Warthin, M.D., Ph.D., (1866–1931) pioneer in hereditary cancer research. Fig. 22.2 Pedigree family G . This family was described in the first published systematic evaluation of…

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