HEMATOLOGY

Myelodysplastic Syndromes

Apr 3, 2021 by in HEMATOLOGY Comments Off on Myelodysplastic Syndromes

General Overview Myelodysplastic syndromes (MDSs) represent a heterogeneous group of myeloid neoplasms characterized by abnormal differentiation and maturation of myeloid cells, ineffective hematopoiesis, and increased risk of transformation to acute…

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Hodgkin Lymphoma

Apr 3, 2021 by in HEMATOLOGY Comments Off on Hodgkin Lymphoma

General Overview and Incidence • Definition of Hodgkin lymphoma (HL): lymphoid neoplasm affecting lymph nodes; paucity of neoplastic cells with rich inflammatory background • Classic Hodgkin lymphoma (cHL) 90% to…

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Acute Myeloid Leukemia

Apr 3, 2021 by in HEMATOLOGY Comments Off on Acute Myeloid Leukemia

A Brief Overview of Acute Myeloid Leukemia Acute myeloid leukemia (AML) is understood to be the product of genetic and epigenetic changes within a multipotent myeloid stem/progenitor cell that generate…

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Mast Cell and Non-Myeloproliferative Myeloid Neoplasms

Apr 3, 2021 by in HEMATOLOGY Comments Off on Mast Cell and Non-Myeloproliferative Myeloid Neoplasms

General Overview and Incidence Mastocytosis is no longer under the broad category of myeloproliferative neoplasm (MPN). Mastocytosis is a heterogeneous disease of clonal neoplastic proliferation and expansions of mast cells…

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Myeloproliferative Neoplasms

Apr 3, 2021 by in HEMATOLOGY Comments Off on Myeloproliferative Neoplasms

General Overview Myeloproliferative neoplasms (MPNs) are clonal stem cell disorders characterized by abnormal chronic proliferation of cells belonging to myeloid lineages that are often associated with elevated blood counts, splenomegaly,…

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Hypochromic and Hemolytic Anemias

Apr 3, 2021 by in HEMATOLOGY Comments Off on Hypochromic and Hemolytic Anemias

Introduction This chapter reviews two separate and partially overlapping types of anemia: hypochromic anemias, resulting from a decreased amount of hemoglobin in red blood cells, and hemolytic anemias, resulting from…

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Megaloblastic Anemia

Apr 3, 2021 by in HEMATOLOGY Comments Off on Megaloblastic Anemia

In the workup of patients with suspected megaloblastic anemia, clinical findings, the complete blood count (CBC) with manual differential, and additional diagnostic studies are critical for narrowing the differential diagnosis…

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Growth Factors

Apr 3, 2021 by in HEMATOLOGY Comments Off on Growth Factors

Hematopoietic Cytokines and Growth Factors Hematopoietic homeostasis is tightly controlled by a group of hematopoietic cytokines ( Fig. 2.1 ). Each cytokine performs unique and/or multiple actions mediated by receptors…

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Normal Hematopoiesis and Blood Cell Maturation

Apr 3, 2021 by in HEMATOLOGY Comments Off on Normal Hematopoiesis and Blood Cell Maturation

Hematopoietic Development Hematopoiesis is the process by which the various cellular components of the blood are formed. The short-term need for these components can be highly variable, but evidence has…

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