HEMATOLOGY

Hemostasis and Platelet Disorders

Nov 20, 2018 by in HEMATOLOGY Comments Off on Hemostasis and Platelet Disorders

Hemostasis and Platelet Disorders Marcia Paddock, MD, PhD John V. Mitsios, PhD Maria T. DeSancho, MD, MSc HEMOSTASIS AND ITS ROLE IN DISEASE Hemostasis Hemostasis is the process by which…

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Anemia

Nov 20, 2018 by in HEMATOLOGY Comments Off on Anemia

Anemia Joshua A. Hayden, PhD Babette B. Weksler, MD The criteria for anemia depend upon age, gender, ethnicity, and pregnancy status. The World Health Organization (WHO) has defined anemia as…

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Techniques for Assessing Blood Disorders: Flow Cytometry, Multiplex Immunohistochemistry, Karyotyping, FISH, and Molecular Approaches

Nov 20, 2018 by in HEMATOLOGY Comments Off on Techniques for Assessing Blood Disorders: Flow Cytometry, Multiplex Immunohistochemistry, Karyotyping, FISH, and Molecular Approaches

Techniques for Assessing Blood Disorders: Flow Cytometry, Multiplex Immunohistochemistry, Karyotyping, FISH, and Molecular Approaches Scott A. Ely, MD, MPH New techniques, platforms, and companies spring into view on a regular…

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Primary Hemophagocytic Lymphohistiocytosis

Dec 5, 2017 by in HEMATOLOGY Comments Off on Primary Hemophagocytic Lymphohistiocytosis

Disease Defective gene Protein Inheritance Protein function FHL syndromes without hypopigmentation FHL2 PRF1 Perforin AR Pore formation FHL3 UNC13D Munc13-4 AR Vesicle priming FHL4 STX11 Syntaxin11 AR Vesicle fusion FHL5…

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Acute Lymphoblastic Leukemia

Dec 5, 2017 by in HEMATOLOGY Comments Off on Acute Lymphoblastic Leukemia

Study group Trial Years ALL subtypes No. of patients Age EFS, % (year) OS, % (year) Reference AIEOP/BFM AIEOP-BFM ALL 2000 2000–2006 B-ALL 4016 1–18 80.4 (7) 91.8 (7) Conter…

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Langerhans Cell Histiocytosis

Dec 5, 2017 by in HEMATOLOGY Comments Off on Langerhans Cell Histiocytosis

Disease Clinical characteristic Histologic features CD1a CD14 CD68 CD163 CD207 S100 Factor XIIIa Fascin HLA-DR Others Langerhans cell histiocytosis See text + − +/− − + + − − +…

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