Diagnosis and Classification of Lymphomas William R. Macon Paul J. Kurtin Ahmet Dogan SPECIMEN EVALUATION Tissue Sampling and Processing Precise assessment of hematopathologic specimens depends, in large part, on adequate…
Systemic Mastocytosis Dean D. Metcalfe HISTORICAL BACKGROUND Mastocytosis is a heterogeneous disease characterized by the abnormal growth and accumulation of mast cells in one or more organs. The first case…
Eosinophilic Neoplasms and Hypereosinophilic Syndrome Huong (Marie) Nguyen Jason Gotlib HISTORICAL BACKGROUND Paul Ehrlich’s use of aniline dyes facilitated identification of the eosinophil as a unique leukocyte in 1879.1 Reactive…
Myelofibrosis Rami Komrokji Eric Padron Srdan Verstovsek DEFINITION Myelofibrosis (MF) is a rare, serious myeloid malignancy classified as one of the Philadelphia chromosome negative [Ph(-)] myeloproliferative neoplasms (MPNs).1 MF is…
Polycythemia Vera Robert T. Means, Jr. DEFINITION AND HISTORY Polycythemia vera (PV), also called polycythemia rubra vera, is a chronic clonal myeloproliferative disorder characterized by a striking absolute increase in…
Pathology of the Myeloproliferative Neoplasms Luke R. Shier Tracy I. George The myeloproliferative neoplasms include both chronic myeloproliferative disorders and overlap myelodysplastic/myeloproliferative syndromes. This chapter reviews the pathology of the…
Chronic Myeloid Leukemia Michael W.N. Deininger HISTORICAL PERSPECTIVE Chronic myeloid leukemia (CML), although a rare disease, has disproportionately influenced hematology/oncology and modern medicine. Reports of what was probably CML date…
The Myelodysplastic Syndromes Guillermo Garcia-Manero ABSTRACT The myelodysplastic syndromes (MDS) are a very complex group of myeloid disorders characterized by peripheral blood cytopenias and morphologic evidence of dysplasia in bone…
Acute Myeloid Leukemia in Adults Ashkan Emadi Maria R. Baer Acute myeloid leukemia, acute myelogenous leukemia, and acute nonlymphocytic leukemia are equivalent terms for a hematopoietic neoplasm that is uniformly…
Acute Promyelocytic Leukemia Jeffrey E. Lancet Peter Maslak Steven L. Soignet Acute myelogenous leukemia (AML) is a malignant disorder of the bone marrow where a maturational arrest in blood cell…
