Diabetes in Minorities in the United States A. Enrique Caballero As human beings, we all share innumerable biologic, psychological, spiritual, and social elements. At the same time, we are each…

Syndromes of Extreme Insulin Resistance Allison B. Goldfine Alan C. Moses Glucose homeostasis depends on a balance between the production of glucose predominantly by the liver and the utilization of…

Secondary Forms of Diabetes Om P. Ganda The term secondary diabetes generally refers to diabetes or glucose intolerance that develops in association with disorders (or factors) other than those currently…

Maturity-Onset Diabetes of the Young Andrew T. Hattersley The early clinical descriptions recognized that maturity-onset diabetes of the young (MODY) was a monogenic form of diabetes with a single gene…

β-Cell Dysfunction in Type 2 Diabetes Mellitus Jack L. Leahy Type 2 diabetes mellitus is a worldwide health crisis; the World Health Organization predicts an incidence of 300 million by…

Insulin Resistance and Its Role in the Pathogenesis of Type 2 Diabetes Meredith Hawkins Luciano Rossetti The term insulin resistance generally refers to resistance to the metabolic effects of insulin,…

Type 1 Diabetes Mellitus George S. Eisenbarth FORMS OF TYPE 1 DIABETES During the past two decades, an accumulating body of information has led to the recognition that the predominant…

Genetics of Type 2 Diabetes Alessandro Doria Type 2 diabetes, or non-insulin-dependent diabetes (NIDDM), is one of the most common metabolic disorders affecting humans. Approximately 14 million Americans have been…

Genetics of Type 1 Diabetes Helena Reijonen Patrick Concannon It has long been recognized that certain forms of diabetes cluster within families. In families with type 1 diabetes, the risk…

Epidemiology of Diabetes Mellitus James H. Warram Andrzej S. Krolewski In this chapter, we will review the descriptive epidemiology of type 1 and type 2 diabetes mellitus and discuss its…