Topoisomerase Inhibitors: Camptothecins, Anthracyclines, and Etoposide Bruce A. Chabner Topoisomerases carry out the important function of unwinding DNA by creating temporary breaks in DNA, promoting passage of single strands of…
Related posts: Pancreatic Cancer Antiestrogens Rectal Cancer Cholangiocarcinoma and Gallbladder Cancers Localized Prostate Cancers Colon Cancer
Breast Oncology: Clinical Presentation and Genetics Amy Comander, Tessa Cigler, Paula D. Ryan EPIDEMIOLOGY In the United States, breast cancer is the most commonly diagnosed cancer among women and is…
Antimetabolites: Nucleoside and Base Analogs Bruce A. Chabner ANALOGS OF DNA PRECURSORS; GENERAL CONSIDERATIONS The synthesis of new DNA is an essential step in the replication of normal and malignant…
Metastatic Breast Cancer Steven J. Isakoff INTRODUCTION Since 1990, the annual rate of breast cancer death has been decreasing by approximately 2.2% per year (1). Historically, median survival of patients…
Ovarian Cancer Richard T. Penson INTRODUCTION Ovarian cancer remains the most lethal of gynecologic malignancies in developed countries. Initial management is aimed at maximal cytoreduc-tion by surgery either before or…
Overview of Clinical Bone Marrow Transplantation Sarah Nikiforow, Thomas R. Spitzer INTRODUCTION Bone marrow or hematopoietic cell transplantation (BMT or HCT) is a potentially curative therapy for a wide variety…
Cancer and Coagulopathy Rachel P.G. Rosovsky INTRODUCTION The association between cancer and thrombosis was first proposed by Armand Trousseau (Figure 19-1) when he recognized the condition of thrombophlebitis migrans, as…
Esophageal and Gastric Canc Lawrence S. Blaszkowsky The incidence of esophageal cancer has steadily increased while the incidence of gastric cancer has decreased in the United States for over a…
