Hematopoietic Neoplasms: Principles of Pathologic Diagnosis Daniel A. Arber The hematopoietic neoplasms consist of acute and chronic leukemias, Hodgkin and non-Hodgkin lymphomas, plasma cell tumors, and the rare histiocytic and…
Disorders of the Spleen Matthew R. Porembka Majella Doyle William C. Chapman The spleen is a small, purplish, sponge-like organ found in the left upper abdominal quadrant.1 Although there is…
Acquired Immunodeficiency Syndrome Ariela Noy Roy M. Gulick HUMAN IMMUNODEFICIENCY VIRUS INFECTION AND ACQUIRED IMMUNODEFICIENCY SYNDROME Human immunodeficiency virus (HIV) infection is a true pandemic, an infection that affects individuals…
Primary Immunodeficiency Syndromes Troy R. Torgerson INTRODUCTION The primary immunodeficiency disease (PIDD) are a group of clinical syndromes originally described in patients with marked susceptibility to particular types of infections….
Infectious Mononucleosis and Other Epstein-Barr Virus-Related Disorders Thomas G. Gross Epstein-Barr virus (EBV) infects the majority of human individuals but usually results in subclinical infections. EBV has been etiologically linked…
Pathology of Langerhans Cell Histiocytosis and Other Histiocytic Proliferations Karen L. Chang Lawrence M. Weiss Langerhans cell histiocytosis and other dendritic and histiocytic neoplasms and related proliferations are uncommon diseases.1…
Langerhans Cell Histiocytosis Suman Malempati H. Stacy Nicholson Langerhans cell histiocytosis (LCH) is a disorder characterized by clonal proliferation of cells in the mononuclear phagocyte system. Since the first case…
Lysosomal Abnormalities of the Monocyte-Macrophage System: Gaucher and Niemann-Pick Diseases Margaret M. McGovern Robert J. Desnick Abnormalities of the monocyte-macrophage system include certain of the inherited lysosomal storage diseases that…
Qualitative Disorders of Leukocytes Ashish Kumar Keith M. Skubitz DISORDERS OF PHAGOCYTIC LEUKOCYTES CHARACTERIZED BY MORPHOLOGIC CHANGES For the most part, the disorders considered here are rare, are usually familial,…
Neutropenia Caron A. Jacobson Nancy Berliner INTRODUCTION The normal range for the peripheral white blood count (WBC) is between 4.5 × 109/L and 10.0 × 109/L, with a mean of…
