Sideroblastic Anemias Sylvia S. Bottomley The sideroblastic anemias are a heterogeneous group of disorders1,2 and 3 uniquely characterized by pathologic iron deposits in erythroblast mitochondria4,5 (Fig. 24.1A) that are housed…
Iron Deficiency and Related Disorders Lawrence T. Goodnough Elizabeta Nemeth Iron deficiency has been recognized since medieval times. Chlorosis, a term derived from the Greek word meaning green, was applied…
Anemia: General Considerations Robert T. Means, Jr. Bertil Glader This introductory chapter focuses on the general concepts of anemia, the classification of the most common types of anemia, the approach…
Transfusion Medicine Susan A. Galel Magali J. Fontaine Maurene K. Viele Christopher L. Gonzalez Lawrence T. Goodnough The first documented transfusion of blood in humans occurred in 1667, but it…
Red Cell, Platelet, and White Cell Antigens Kathryn E. Webert James W. Smith Donald M. Arnold Howard H. W. Chan Nancy M. Heddle John G. Kelton INTRODUCTION This chapter reviews…
Endothelium: Angiogenesis and the Regulation of Hemostasis Paul J. Shami George M. Rodgers NORMAL ANGIOGENESIS Blood circulation requires the production and maintenance of a vast network of vessels that have…
Platelet Function in Hemostasis and Thrombosis David C. Calverley PLATELET ADHESION AND ACTIVATION Primary hemostasis and arterial thrombosis are the results of a complex series of cell-cell, cell-protein, and protein-protein…
Platelet Structure and Function in Hemostasis and Thrombosis Susan S. Smyth PLATELET STRUCTURE Structural and Functional Anatomy Light Microscopy Light microscopy of Wright-stained smears (Fig. 16.1) reveals platelets as small,…
Effector Mechanisms in Immunity Frixos Paraskevas MAJOR HISTOCOMPATIBILITY COMPLEX The function of the immune system is under genetic control1 and molecular genetic studies have helped to elucidate the mechanism of…
Megakaryocytes Amy E. Geddis Megakaryocytes are large polyploid cells within the bone marrow that produce circulating platelets. Platelets are small anucleate cells that play an essential role in hemostasis, both…
