Acute Lymphoblastic Leukemia in Adults
Acute Lymphoblastic Leukemia in Adults Steven E. Coutre Acute lymphoblastic leukemia (ALL) is a neoplastic disorder that is rapidly fatal if untreated. In children, ALL is the most common malignancy,…
HEMATOLOGY
Diagnosis and Classification of the Acute Leukemias and Myelodysplastic Syndromes
Diagnosis and Classification of the Acute Leukemias and Myelodysplastic Syndromes Daniel A. Arber Attilio Orazi INTRODUCTION The diagnosis and classification of acute leukemias and myelodysplastic syndromes (MDSs) has grown increasingly…
Molecular Genetics of Acute Leukemia
Molecular Genetics of Acute Leukemia Mary Ann Thompson Utpal P. Davé INTRODUCTION Acute leukemia results when a normal hematopoietic stem or progenitor cell sequentially acquires mutations which confer clonal growth…
Gene Therapy for Hematologic Disorders
Gene Therapy for Hematologic Disorders Andre Larochelle Cynthia E. Dunbar John Tisdale INTRODUCTION The molecular characterization of congenital and acquired human disease over the past several decades has stimulated scientists…
Immunotherapy
Immunotherapy Adetola A. Kassim Sattva S. Neelapu Larry W. Kwak Luc Van Kaer HISTORY There probably is no field in medicine that has provided as much hope, or as much…
Supportive Care in Hematologic Malignancies
Supportive Care in Hematologic Malignancies Andrew J. Moore Mary A. Vu Stephen A. Strickland Patients with hematologic neoplasms are at significant risk for complications both from the malignancy as well…
Principles and Pharmacology of Chemotherapy
Principles and Pharmacology of Chemotherapy Kenneth R. Hande PRINCIPLES OF CHEMOTHERAPY To optimally treat cancer patients, clinicians should understand the principles of cancer chemotherapy as well as the pharmacology of…
Tumors of the Spleen
Tumors of the Spleen Daniel A. Arber A variety of tumors and tumorous proliferations may involve the spleen, and there are several that are unique to this organ. This chapter…
Hematopoietic Neoplasms: Principles of Pathologic Diagnosis
Hematopoietic Neoplasms: Principles of Pathologic Diagnosis Daniel A. Arber The hematopoietic neoplasms consist of acute and chronic leukemias, Hodgkin and non-Hodgkin lymphomas, plasma cell tumors, and the rare histiocytic and…
Disorders of the Spleen
Disorders of the Spleen Matthew R. Porembka Majella Doyle William C. Chapman The spleen is a small, purplish, sponge-like organ found in the left upper abdominal quadrant.1 Although there is…
