Hereditary Spherocytosis, Hereditary Elliptocytosis, and Other Disorders Associated with Abnormalities of the Erythrocyte Membrane Patrick G. Gallagher Bertil Glader This chapter focuses on hemolytic disorders and abnormalities of red blood…
Porphyrias Sylvia S. Bottomley The porphyrias are diverse disorders that arise from various inherited enzyme defects in the heme biosynthesis pathway (Fig. 26.1). The first authentic cases of porphyria were…
Hemochromatosis Corwin Q. Edwards James C. Barton IRON OVERLOAD Iron overload can result from any process that causes iron accumulation in excess of iron loss. Examples of such processes include…
Sideroblastic Anemias Sylvia S. Bottomley The sideroblastic anemias are a heterogeneous group of disorders1,2 and 3 uniquely characterized by pathologic iron deposits in erythroblast mitochondria4,5 (Fig. 24.1A) that are housed…
Iron Deficiency and Related Disorders Lawrence T. Goodnough Elizabeta Nemeth Iron deficiency has been recognized since medieval times. Chlorosis, a term derived from the Greek word meaning green, was applied…
Anemia: General Considerations Robert T. Means, Jr. Bertil Glader This introductory chapter focuses on the general concepts of anemia, the classification of the most common types of anemia, the approach…
Transfusion Medicine Susan A. Galel Magali J. Fontaine Maurene K. Viele Christopher L. Gonzalez Lawrence T. Goodnough The first documented transfusion of blood in humans occurred in 1667, but it…
Red Cell, Platelet, and White Cell Antigens Kathryn E. Webert James W. Smith Donald M. Arnold Howard H. W. Chan Nancy M. Heddle John G. Kelton INTRODUCTION This chapter reviews…
Endothelium: Angiogenesis and the Regulation of Hemostasis Paul J. Shami George M. Rodgers NORMAL ANGIOGENESIS Blood circulation requires the production and maintenance of a vast network of vessels that have…
Platelet Function in Hemostasis and Thrombosis David C. Calverley PLATELET ADHESION AND ACTIVATION Primary hemostasis and arterial thrombosis are the results of a complex series of cell-cell, cell-protein, and protein-protein…
