Monoclonal Gammopathies of Undetermined Significance and Smoldering Multiple Myeloma S. Vincent Rajkumar Robert A. Kyle John A. Lust INTRODUCTION Nomenclature Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic, pre-malignant…
Molecular Genetic Aspects of Plasma Cell Disorders P. Leif Bergsagel A. Keith Stewart Stephen J. Russell Rafael Fonseca INTRODUCTION Multiple myeloma (MM) is an age-dependent monoclonal tumor of bone marrow…
Hodgkin Lymphoma in Children Debra L. Friedman INTRODUCTION The first description of Hodgkin lymphoma (HL) was in 1832 when Thomas Hodgkin described seven patients with enlarged lymph glands and spleen….
Practical Approach to Evaluation of Monoclonal Gammopathies Francis K. Buadi Joseph R. Mikhael William G. Morice II The real incidence of monoclonal gammopathy is unknown; however, it increases with age,…
Hodgkin Lymphoma in Adults David S. Morgan Kristie A. Blum Hodgkin lymphoma (HL) is a lymphoproliferative malignancy that accounts for only 1% of newly diagnosed malignancies in the United States;…
Cutaneous T-Cell Lymphoma: Mycosis Fungoides and Sézary Syndrome John A. Zic Jeff P. Zwerner Laura Y. McGirt Claudio A. Mosse John P. Greer Cutaneous lymphomas are a heterogeneous group of…
Hairy Cell Leukemia James B. Johnston Michael R. Grever Hairy cell leukemia (HCL), or leukemic reticuloendotheliosis, is a chronic B-cell disorder that was initially described by Bouroncle et al. in…
Chronic Lymphocytic Leukemia James B. Johnston Matthew Seftel Spencer B. Gibson Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of mature-appearing lymphocytes in the blood, marrow, lymph nodes, and…
Non-Hodgkin Lymphoma in Children John T. Sandlund, Jr. Mihaela Onciu INTRODUCTION There have been significant clinical and laboratory advances over the last 25 years in our understanding of the non-Hodgkin…
Non-Hodgkin Lymphoma in Adults John P. Greer Nishitha M. Reddy Michael E. Williams HISTORICAL PERSPECTIVE Thomas Hodgkin was the first to recognize that lymphadenopathy could occur as a primary disorder…
