Cryosurgery
Fig. 23.1 Arrows show the flow of heat (FH) differences between different materials In a fast frozen tissue, temperature drops can be visualized as isotherms being at the center of…
Dermoscopy
Fig. 13.1 Clinical image (left upper corner) and dermoscopy of a nevus showing symmetry in the distribution of colors and structures and predominantly one color (brown). The predominant pattern is…
Radiation Therapy in Dermatology
Advantages Outpatient treatment, even for tumours covering large areas Healthy tissue can be preserved Large safety margins possible (a decisive advantage over surgical excision margins that tend to be marginal…
Electrochemotherapy in Dermatological Oncology
where k is a form factor accounting for the impact of the cell on the extracellular field distribution, r is the radius of the cell (assumed to be spherical), θ…
Use of 22 MHz High-Frequency Ultrasound in the Management of Skin Cancer
Fig. 15.1 Clinical (a), dermoscopic (b), and HFUS/HRUS (c) images of a retroauricular basal cell carcinoma (BCC) Fig. 15.2 Clinical (a), dermoscopic (b), and HFUS/HRUS (c) images of a squamous…
Primary Cutaneous Lymphomas
Mature T-cell and NK-cell neoplasms Mature B-Cell neoplasms Mycosis fungoides Cutaneous marginal zone B-cell lymphoma (MALT type) Pagetoid reticulosis (localised disease) Cutaneous follicle centre lymphoma Follicular, syringotropic, granulomatous variants Cutaneous…
Optical Coherence Tomography
Fig. 16.1 In FD-OCT, each depth scan is performed by sampling the interference pattern in optical frequency space, either with a spectrometer and a broadband light source (a) or with…
Molecular Pathology of Melanocytic Skin Cancer
Fig. 4.1 Major pathways involved in melanoma. Arrows, activating signals; interrupted lines, inhibiting signals. CDKN2A cyclin-dependent kinase inhibitor of kinase 2A, CDK2/4/6 cyclin-dependent kinase 2/4/6, MDM2 murine double minute 2…
Mohs Micrographic Surgery
Fig. 21.1 MMS technique (1). Debulking. The visible tumour is debulked with scalpel (2). Excision of 1–2 mm of healthy tissue surrounding the wound resulting from debulking (3). The specimen…
Gene Expression Profiling in Melanoma
Fig. 36.1 Schematic representation of the double- and single-channel array technologies. The two methods differ in the sample preparation and labelling procedures. A typical microarray experiment consists in the expression…
