Thrombosis and Antithrombotic Therapy
Thrombosis and Antithrombotic Therapy Robert C. Pendleton George M. Rodgers The term thrombosis refers to the formation, from constituents of the blood, of a mass within the venous or arterial…
Acquired Coagulation Disorders
Acquired Coagulation Disorders George M. Rodgers Abnormalities in blood coagulation may complicate a large number of disorders (Table 54.1). In contrast to inherited disorders in which deficiency or abnormality of…
Inherited Coagulation Disorders
Inherited Coagulation Disorders Jerry S. Powell George M. Rodgers Inherited disorders of coagulation result from the deficiency or functional abnormality of one of the plasma proteins involved in providing normal…
Qualitative Disorders of Platelet Function
Qualitative Disorders of Platelet Function Thomas J. Kunicki Diane J. Nugent Much of our current understanding of normal platelet structure-function relationships has been derived from the study of patients with…
Thrombocytosis and Essential Thrombocythemia
Thrombocytosis and Essential Thrombocythemia George M. Rodgers Robert T. Means, Jr. The normal reference interval for platelet counts in adults approximates 150,000 to 450,000/µl; patients with platelet counts higher than…
Bleeding Disorders Caused by Vascular Abnormalities
Bleeding Disorders Caused by Vascular Abnormalities George M. Rodgers Matthew M. Rees This chapter discusses causes of bleeding that are not the result of thrombocytopenia, coagulation factor deficiency, or qualitative…
Miscellaneous Causes of Thrombocytopenia
Miscellaneous Causes of Thrombocytopenia Archana M. Agarwal George M. Rodgers This chapter summarizes miscellaneous forms of congenital and acquired thrombocytopenia (Table 49.1), including thrombocytopenia attributable to deficient platelet production, associated…
Thrombotic Thrombocytopenic Purpura, Hemolytic-Uremic Syndrome, and Related Disorders
Thrombotic Thrombocytopenic Purpura, Hemolytic-Uremic Syndrome, and Related Disorders Han-Mou Tsai The various forms of thrombocytopenia discussed in this chapter share the common features of thrombocytopenia and hemolysis with characteristic schistocytes…
Thrombocytopenia Caused by Immunologic Platelet Destruction
Thrombocytopenia Caused by Immunologic Platelet Destruction Meghan S. Liel Michael Recht David C. Calverley Immune thrombocytopenia (ITP) occurs when platelets undergo premature destruction as a result of autoantibody or immune…
Thrombocytopenia: Pathophysiology and Classification
Thrombocytopenia: Pathophysiology and Classification George M. Rodgers PATHOPHYSIOLOGY Thrombocytopenia may be defined as a subnormal number of platelets in the circulating blood. It is the most common cause of abnormal…
