Disorders of the Spleen
Disorders of the Spleen Matthew R. Porembka Majella Doyle William C. Chapman The spleen is a small, purplish, sponge-like organ found in the left upper abdominal quadrant.1 Although there is…
Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome Ariela Noy Roy M. Gulick HUMAN IMMUNODEFICIENCY VIRUS INFECTION AND ACQUIRED IMMUNODEFICIENCY SYNDROME Human immunodeficiency virus (HIV) infection is a true pandemic, an infection that affects individuals…
Primary Immunodeficiency Syndromes
Primary Immunodeficiency Syndromes Troy R. Torgerson INTRODUCTION The primary immunodeficiency disease (PIDD) are a group of clinical syndromes originally described in patients with marked susceptibility to particular types of infections….
Infectious Mononucleosis and Other Epstein-Barr Virus-Related Disorders
Infectious Mononucleosis and Other Epstein-Barr Virus-Related Disorders Thomas G. Gross Epstein-Barr virus (EBV) infects the majority of human individuals but usually results in subclinical infections. EBV has been etiologically linked…
Pathology of Langerhans Cell Histiocytosis and Other Histiocytic Proliferations
Pathology of Langerhans Cell Histiocytosis and Other Histiocytic Proliferations Karen L. Chang Lawrence M. Weiss Langerhans cell histiocytosis and other dendritic and histiocytic neoplasms and related proliferations are uncommon diseases.1…
Langerhans Cell Histiocytosis
Langerhans Cell Histiocytosis Suman Malempati H. Stacy Nicholson Langerhans cell histiocytosis (LCH) is a disorder characterized by clonal proliferation of cells in the mononuclear phagocyte system. Since the first case…
Lysosomal Abnormalities of the Monocyte-Macrophage System: Gaucher and Niemann-Pick Diseases
Lysosomal Abnormalities of the Monocyte-Macrophage System: Gaucher and Niemann-Pick Diseases Margaret M. McGovern Robert J. Desnick Abnormalities of the monocyte-macrophage system include certain of the inherited lysosomal storage diseases that…
Qualitative Disorders of Leukocytes
Qualitative Disorders of Leukocytes Ashish Kumar Keith M. Skubitz DISORDERS OF PHAGOCYTIC LEUKOCYTES CHARACTERIZED BY MORPHOLOGIC CHANGES For the most part, the disorders considered here are rare, are usually familial,…
Neutropenia
Neutropenia Caron A. Jacobson Nancy Berliner INTRODUCTION The normal range for the peripheral white blood count (WBC) is between 4.5 × 109/L and 10.0 × 109/L, with a mean of…
Diagnostic Approach to Malignant and Nonmalignant Disorders of the Phagocytic and Immune Systems
Diagnostic Approach to Malignant and Nonmalignant Disorders of the Phagocytic and Immune Systems Daniel A. Arber Thomas L. McCurley John P. Greer Cost-effective, efficient evaluation of patients with hematologic diseases…
