Mantle Cell Lymphoma
Better prognosis Poorer prognosis MIPIa score (Geisler et al. 2010) Low Intermediate or high MIPI-bb score (Schaffel et al. 2010) Low Intermediate or high Posttreatment MRDc (Pott et al….
Cytogenetics
Fig. 2.1 Application of FISH in lymphoma diagnostics and research. (a) Scheme of the dual-color, break-apart probe for BCL6 translocations (www.abbottmolecular.com); Scheme of the dual-color, dual-fusion translocation probe for the…
CNS Lymphoma
Fig. 11.1 A rare case of primary CNS lymphoplasmacytic lymphoma demonstrating a perivascular lymphoid infiltrate (10×) composed of lymphoplasmacytic cells (400×) Fig. 11.2 Lymphoplasmacytic lymphoma from Fig. 11.1 showing the…
Cutaneous T-Cell Lymphoma
Indolent subtypes Frequency (%) Aggressive subtypes Frequency (%) Mycosis fungoides variants and subtypes 61 Sézary syndrome 4 Folliculotropic mycosis fungoides 6 Adult T-cell leukemia/lymphoma <1 Pagetoid reticulosis <1 Extranodal NK/T-cell…
Primary Cutaneous B-Cell Lymphomas
T T1: Solitary skin involvement T1a: A solitary lesion <5 cm diameter T1b: A solitary >5 cm diameter T2: Regional skin involvement: multiple lesions limited to one body region or…
Extranodal NK/T-Cell Lymphoma, Nasal Type
Fig. 7.1 (a) Extranodal NK/T-cell lymphoma of the nasal cavity. Small- to medium-sized tumor cells are intermingled with plasma cells. (b) EBER in situ hybridization revealed positive signal in the…
HIV-Associated Lymphomas
Fig. 12.1 Burkitt lymphoma. (a) In this example of a Burkitt lymphoma arising in the gastric wall of an HIV-positive patient, the tumor cells are slightly larger and more pleomorphic…
Primary Mediastinal Large B-Cell Lymphoma
Fig. 10.1 Primary mediastinal B-cell lymphoma: (a) H&E staining, consists of the neoplastic large cells with clear cytoplasm, (b) fibrotic bands with compartmentalising alveolar fibrosis, (c) tumour cells express CD30…
Waldenström’s Macroglobulinemia
Fig. 16.1 Fundoscopic examination of a patient with Waldenström’s macroglobulinemia demonstrating hyperviscosity-related changes including dilated retinal vessels, peripheral hemorrhages, and “venous sausaging” (Courtesy of Marvin Stone M.D.) 16.3.2 Immunophenotype The…
Mucosal-Associated Lymphoid Tissue (MALT) Lymphoma
Fig. 14.1 Path slides to be chosen by pathologist Other cytogenetic abnormalities that have been reported in MALT lymphomas include t(11;18), t(14;18), t(1;14), t(3;14), and trisomy 8. The translocation t(11;18)…
