Lung Cancer Stem Cells Timothy Craig Allen Although lung stem cells and the hypothesis of lung cancer stem cells do not fit the typical paradigm of preneoplastic and preinvasive lesions,…

Atypical Adenomatous Hyperplasia Keith M. Kerr This chapter considers the current theories of adenocarcinogenesis in the human lung and the place that atypical adenomatous hyperplasia (AAH) has in this process….

Bronchial Squamous Dysplasia and Carcinoma In Situ Keith M. Kerr This chapter will review squamous dysplasia and carcinoma in situ (SD/CIS), recognized in the WHO classification of lung tumors as…

New Staging System for Lung Cancer Philip T. Cagle THE NEW TNM STAGING SYSTEM FOR LUNG CANCER As noted in the previous chapter, the TNM staging system for lung cancer,…

Problems in the Staging of Lung Cancer Philip T. Cagle THE TNM STAGING SYSTEM The stage, or anatomic extent, of a cancer at the time of diagnosis is one of…

Molecular Prognostic Markers of Lung Cancer Sanja Dacic Many studies have examined potentially prognostic genetic changes in lung carcinoma using different methodologies from immunohistochemistry to gene expression profiling. However, no…

Molecular Targeted Therapy of Lung Cancer Sanja Dacic The most frequently targeted pathways in non-small cell lung carcinomas (NSCLC) have involved the epidermal growth factor receptor (EGFR), vascular endothelial growth…

Molecular Diagnostics of Lung Cancer Sanja Dacic The diagnosis of lung carcinoma is largely based on morphology. Ancillary tools such as histochemical stains and immunohistochemistry are used in occasional cases….

Multimodality Theranostics and Molecular Imaging in the Diagnosis and Treatment of Lung Cancer Kirtee Raparia Kelvin Wong Stephen Wong King C. Li Philip T. Cagle Development of image-guided, multimodality diagnostic…

Metastatic Tumors to the Lung Timothy Craig Allen Metastatic tumors to the lungs are the most common lung neoplasm, and the lungs are the recipient of more metastatic neoplasms than…