Fig. 25.1 (a) Manual and automated identification of antigen-specific MHC class I multimer-positive CD8+ T lymphocytes among PBMC of a HLA-A2+ healthy donor. Top panel shows a manual gating strategy…

Fig. 13.1 Functional classification of cell death modalities as described by the Nomenclature Committee on Cell Death (NCCD) [19] 13.2 Mechanisms of Apoptosis The term “apoptosis” was introduced by Kerr…

Fig. 9.1 CD95: mRNA to protein Once docked on CD95-DD, FADD self-associates [71] and binds procaspases-8 and procaspases-10, which are auto-processed and released in the cytosol as active caspases, which…

Fig. 10.1 GR9 fibrosarcoma tumor model. Cell clones are adapted to tissue culture from the primary tumor and classified according to MHC-I surface expression The intratumoral heterogeneity in H-2 class…

Fig. 20.1 Schematic overview of complex network of diet-immunity-cancer Fig. 20.2 The casual pathways of cachexia occurrence after malignancy It should be noted that antitumor agents with their side effect…

Fig. 5.1 T cell activation requires recognition of the antigen and costimulatory signals. Inflammation generated by tissue damage or infections activates antigen-presenting cells (APCs) and stimulates the expression of costimulatory…

Marker Structure/function Ligand Effect of activation BDCA-2/BDCA-4 Associated with FcεRlγ to form a signaling receptor complex ITAM Upon ligation, they inhibit TLR activation and release of type I IFN CD4…