Autophagy and Necroptosis in Cancer
Fig. 14.1 Autophagy signaling pathway and antitumor therapeutic targets 14.2 Autophagy and Cancer The role of autophagy in cancer is rather perplexing. It is widely postulated that the autophagic pathway…
ONCOLOGY
Primary Immunodeficiencies and Cancers
Gene Disease Inheritance Clinical features Pathogenesis Immune defects Associated cancers ATM (OMIM*607585) Ataxia-telangiectasia AR Cerebellar ataxia, oculocutaneous telangiectasia, chromosomal instability, radiosensitivity, thymic aplasia, recurrent sinopulmonary infections, cancer predisposition (up 40…
Role of Cytokines in Tumor Immunity and Immune Tolerance to Cancer
Fig. 7.1 IL-12 links innate and adaptive antitumor immunity. IL-12 utilizes several mechanisms to induce antitumor effects. IL-27 activates innate effectors, such as NK cells, NKT cells, and γδ −…
Epigenetics and microRNAs in Cancer
© Springer-Verlag Berlin Heidelberg 2015Nima Rezaei (ed.)Cancer Immunology10.1007/978-3-662-44006-3_16 16. Epigenetics and microRNAs in Cancer Petra M. Wise1, 2 , Kishore B. Challagundla1, 2 and Muller Fabbri1, 3 (1) Department of Pediatric Hematology/Oncology, Children’s Center for Cancer and Blood Diseases, Norris…
Prognostic Value of Innate and Adaptive Immunity in Cancers
50. Allavena P, Sica A, Garlanda C, Mantovani A. The yin-yang of tumor-associated macrophages in neoplastic progression and immune surveillance. Immunol Rev. 2008;222:155–61.PubMed 51. Bottazzi B, Polentarutti N, Acero R,…
Role of Innate Immunity in Cancers and Antitumor Response
Fig. 3.1 Role of innate immune receptors in the regulation of antitumor immunity. (a) The functions of the innate immune system are regulated by various receptors expressed in immune cells….
Regulatory T Cells and Th17 Cells in Cancer Microenvironment
Fig. 6.1 Potential roles of FoxP3+ T cells and Th17 cells in tumors. (a) FoxP3+ T cells are made in the thymus as naïve-type FoxP3+ T cells, which migrate to…
Inflammatory and Innate Immune Cells in Cancer Microenvironment and Progression
Fig. 2.1 Differentiation pathways of tumor-associated myeloid cells. Myeloid cells originate from hematopoietic stem cells (HSC) in the bone marrow. Here the networks that give rise to the various myeloid…
Introduction on Cancer Immunology and Immunotherapy
© Springer-Verlag Berlin Heidelberg 2015Nima Rezaei (ed.)Cancer Immunology10.1007/978-3-662-44006-3_1 1. Introduction on Cancer Immunology and Immunotherapy Nima Rezaei1, 2 , Seyed Hossein Aalaei-Andabili3, 4 and Howard L. Kaufman5 (1) Department of Immunology, Research Center for Immunodeficiencies, Children’s Medical Center, Pediatrics Center…
Biology of Human Herpesvirus 8: Novel Functions and Virus–Host Interactions Implicated in Viral Pathogenesis and Replication
Fig. 1 ER-localized interactions and activities of vIL-6 in latently infected PEL cells. In the context of PEL latency, vIL-6 is expressed at low but functional levels and is largely sequestered…
