Fig. 7.1 Immunohistochemistry (IHC) of murine testis. (a) Antibody-specific staining of a protein antigen, which is selectively present in male germ cells with maximal levels (dark-brown staining) at spermatogonia-spermatocyte stage,…
Model name Company Patient port size [mm] PET detector ring FDA cleared PET CT Diameter [mm] [year] ECAT Accel CTI (Siemens) 562 N/A 824 2000 Discovery LS GE Healthcare 600…
Diagram 2.1 Epigenetic dysregulation of the metabolic signaling pathways that control cell growth, survival, and chemoresistance mechanisms in DLBCL. Our previous studies have shown that deregulated NF-kB, NFAT, and STAT3…
Fig. 1.1 [18F]FDG Although PET facilities are rapidly increasing worldwide, the only PET radiopharmaceutical currently available for diagnosis is [18F]FDG. In keeping with this notion, [18F]FDG is by far the…
Fig. 9.1 Types of dedicated breast PET scanners. (a) Positron emission mammography (PEM). (b) Fully tomographic dedicated breast PET with dual-plate detector rotating around the breast. (c) Fully tomographic dedicated…
Grade At rest In operation 0.5 pe 5.5 m 0.5 pe 5.5 A 3520 20 3520 20 B 3520 29 352,000 2900 C 352,000 2900 3,520,000 29,000 D 3,520,000 29,000…
Imaging system Isotope Radiotracer Applied animal model Reference SPECT 99mTc 99mTc-BTAP-AnnexinV Atrial thrombi {Stratton, 1995 #4} {Narula, 2001 #5} 99mTc-HYNIC-Annexin V Jurkat T-cell lymphoblasts {Blankenberg, 1999 #3} {Blankenberg, 1999 #3}…
Fig. 6.1 Constructions of guidance documents by FDA concerning medical imaging drug development and radioactive drug clinical research 6.3.1.3 Clinical Trial Network and Standardization Accordingly, more and more quality assurance…
Fig. 12.1 Panel (a) illustrates the pattern of spontaneous systemic metastases that can arise heterogeneously in mice within a month or more after surgical resection of an established primary orthotopic…
Fig. 11.1 Schema for testing agents through the Pediatric Pre-clinical Testing Program (PPTP). Adapted from reference [68] Standard Cytotoxic Agents Responses to standard cytotoxic agents (vincristine, cyclophosphamide, actinomycin D, cisplatinum,…
