The Concept of Onco-Functional Balance in the Management of DLGG
Fig. 33.1 Axial FLAIR-weighted MRI showing a typical illustration of a “false DLGG”, which is in fact a highly diffuse glioblastoma. In its initial phase of low density (left), such…
ONCOLOGY
Emerging Therapies for Diffuse Low Grade Glioma
© Springer-Verlag London Ltd. 2017Hugues Duffau (ed.)Diffuse Low-Grade Gliomas in Adults10.1007/978-3-319-55466-2_29 29. Emerging Therapies for Diffuse Low Grade Glioma James Wright1 and Andrew Edward Sloan1, 2, 3 (1) Department of Neurological Surgery, University Hospitals-Cleveland Medical Center and…
New Individualized and Dynamic Therapeutic Strategies in DLGG
Fig. 28.1 Personalized dynamic multimodal therapeutic strategy in DLGG, with the goal to prevent malignant transformation while preserving quality of life 28.2.1 The Multistage Surgical Attitude As extensively demonstrated in…
Functional Rehabilitation in Patients with DLGG
© Springer-Verlag London Ltd. 2017Hugues Duffau (ed.)Diffuse Low-Grade Gliomas in Adults10.1007/978-3-319-55466-2_27 27. Functional Rehabilitation in Patients with DLGG Guillaume Herbet1, 2, 3 and Sylvie Moritz-Gasser1, 2, 4, 3 (1) National Institute for Health and Medical Research…
Radiation Therapy in the Treatment of Low Grade Gliomas
Fig. 26.1 Proton radiotherapy plan (left) compared to a photon plan with IMRT (right). The proton plan demonstrates decreased low dose spill (green and blue colorwash) compared to the IMRT…
Chemotherapy for Diffuse Low Grade Gliomas
Year Authors and journal N Tumor type Contrast enhancement (%) Prior RT (%) Prior CT (%) Chemotherapy regimen Response rate CR + PR/MR (%) One year PFS (%) Median PFS…
Natural History and Spontaneous Prognostic Factors
Fully validated in clinical trials • Age >40 years • Presence of neurological deficits and/or absence of seizures at onset • Low performance status (Karnofsky <70) • Preoperative tumor diameter >4–6 cm • Astrocytoma as…
Quality of Life in Patients with Diffuse Low-Grade Glioma
© Springer-Verlag London Ltd. 2017Hugues Duffau (ed.)Diffuse Low-Grade Gliomas in Adults10.1007/978-3-319-55466-2_13 13. Quality of Life in Patients with Diffuse Low-Grade Glioma Martin Klein1 (1) Department of Medical Psychology, VU University Medical Center, De Boelelaan 1118,…
Towards an Intermediate Grade in Glioma Classification
Fig. 5.1 Three examples (a = case 1; b = case 2; c = case 3) of microfoci of “intermediate grade” at low magnification (left) and at high magnification (right)…
The Genomics of Diffuse Low-Grade Gliomas
Molecular markers Prevalence (n > 1000 glioma subjects) (%) IDH mutation only 45 Triple-positive [TERTp-mut, IDH-mut, 1p/19q codeletion] 29 TERTp-mutation only 10 Triple negative [TERTp- wild type, IDH-wild type, 1p/19q…
