Abstract Bleeding symptoms presenting in the neonatal period usually present a diagnostic and therapeutic challenge for treating physicians. Bleeding disorders may be due to either congenital or acquired coagulation disorders,…
Abstract In addition to quantitative neutrophil abnormalities, innate immunity, and thus risk of infection in a neonate, may be negatively impacted by qualitative phagocyte defects. The term phagocyte stems from…
Abstract Eosinophilia in neonates is identified when the blood concentration of eosinophils exceeds the upper reference range limit. To avoid the potential pitfall of laboratory or technician error, perhaps the…
Abstract Thrombocytopenia occurs in less than 1% of all newborns. However, thrombocytopenia is a common finding in the intensive-care nursery where it is present in 25–35% of admitted infants [1,…
Abstract Fetal and neonatal alloimmune thrombocytopenia (AIT) is the most common cause of severe thrombocytopenia in fetuses and neonates [1]. Maternal IgG alloantibodies against paternally derived fetal platelet antigens cross…
Abstract In this chapter, we will focus exclusively on acquired thrombocytopenias that present in the neonatal period. We will discuss the mechanisms underlying some of the most common varieties of…
Abstract Over the last decades, as the survival of neonates admitted to the neonatal intensive care unit (NICU) improved, thrombocytopenia became an increasingly important problem in the care of sick…
Abstract Polycythemia of the newborn is first mentioned in the Bible as Esau and Jacob are described at the time of their birth. Esau appears to be the recipient of…
Abstract This chapter focuses on the recognition and management of hemolysis in newborn infants (). Some of the common hemolytic anemias of childhood first appear in the newborn period, while…
Abstract Hemolytic disease of the fetus and newborn (HDFN) is the immune mediated destruction of fetal and neonatal red blood cells by maternal antibody. HDFN occurs when the fetal red…
