Cancer Biology and Hereditary Cancer Syndromes Utkarsh H. Acharya, DO, FACP Tejaswini Dhawale, MD Mutations of the CDH1 gene have been associated with which condition? View Answer Hereditary diffuse gastric…
Clinical Pharmacology and Cancer Therapeutics Utkarsh H. Acharya, DO, FACP Tejaswini Dhawale, MD A patient with stage III colorectal cancer is placed on adjuvant capecitabine and oxaliplatin with a creatinine…
Primary aldosteronism (PA) is uncommon in pregnancy, with fewer than 64 cases reported in the medical literature; most of these reported patients had aldosterone-producing adenomas (APAs). PA can lead to…
As we have highlighted in the other cases, the clinical management of catecholamine-secreting pheochromocytomas or paragangliomas (PPGLs) can be very challenging—both diagnostically and therapeutically. However, when PPGL is diagnosed in…
As we have highlighted in the other cases, the clinical management of catecholamine-secreting pheochromocytomas or paragangliomas (PPGLs) can be challenging—both diagnostically and therapeutically. However, when PPGL is diagnosed in the…
The most common type of congenital adrenal hyperplasia (CAH) is 21-hydroxylase deficiency, which occurs in 1 in 10,000 live births. The goals of therapy in CAH include (1) replacement therapy…
Postmenopausal androgen hypersecretion may be due to an ovarian tumor, an adrenal tumor, or ovarian hyperthecosis. It is important to assess the patient with a full androgen profile and imaging…
As we have highlighted in the other cases, the clinical management of catecholamine-secreting pheochromocytomas or paragangliomas (PPGLs) can be challenging—both diagnostically and therapeutically. However, when PPGL is diagnosed in the…
Pregnancy is a state of physiologic hypercortisolism. Management of adrenal insufficiency during pregnancy includes adjustment of therapy to physiologic needs and avoidance of adrenal crisis through an in-depth education, availability,…
Workup for corticotropin (ACTH)-independent hypercortisolism is required in any patient with an adrenal mass, regardless of symptoms of hormone excess. Unfortunately, only a minority of patients with adrenal incidentalomas undergo…
