Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia Jeffrey E. Lancet Peter Maslak Steven L. Soignet Acute myelogenous leukemia (AML) is a malignant disorder of the bone marrow where a maturational arrest in blood cell…
Acute Myelogenous Leukemia in Children
Acute Myelogenous Leukemia in Children Robert J. Arceci HISTORICAL BACKGROUND Acute myelogenous leukemia (AML) represents a heterogeneous group of hematologic malignancies arising from the transformation and expansion of an early…
Acute Lymphoblastic Leukemia in Children
Acute Lymphoblastic Leukemia in Children Elizabeth A. Raetz Mignon Lee-Chuen Loh Maureen M. O’Brien James A. Whitlock Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy, accounting for approximately…
Acute Lymphoblastic Leukemia in Adults
Acute Lymphoblastic Leukemia in Adults Steven E. Coutre Acute lymphoblastic leukemia (ALL) is a neoplastic disorder that is rapidly fatal if untreated. In children, ALL is the most common malignancy,…
Diagnosis and Classification of the Acute Leukemias and Myelodysplastic Syndromes
Diagnosis and Classification of the Acute Leukemias and Myelodysplastic Syndromes Daniel A. Arber Attilio Orazi INTRODUCTION The diagnosis and classification of acute leukemias and myelodysplastic syndromes (MDSs) has grown increasingly…
Molecular Genetics of Acute Leukemia
Molecular Genetics of Acute Leukemia Mary Ann Thompson Utpal P. Davé INTRODUCTION Acute leukemia results when a normal hematopoietic stem or progenitor cell sequentially acquires mutations which confer clonal growth…
Gene Therapy for Hematologic Disorders
Gene Therapy for Hematologic Disorders Andre Larochelle Cynthia E. Dunbar John Tisdale INTRODUCTION The molecular characterization of congenital and acquired human disease over the past several decades has stimulated scientists…
Immunotherapy
Immunotherapy Adetola A. Kassim Sattva S. Neelapu Larry W. Kwak Luc Van Kaer HISTORY There probably is no field in medicine that has provided as much hope, or as much…
Supportive Care in Hematologic Malignancies
Supportive Care in Hematologic Malignancies Andrew J. Moore Mary A. Vu Stephen A. Strickland Patients with hematologic neoplasms are at significant risk for complications both from the malignancy as well…
Principles and Pharmacology of Chemotherapy
Principles and Pharmacology of Chemotherapy Kenneth R. Hande PRINCIPLES OF CHEMOTHERAPY To optimally treat cancer patients, clinicians should understand the principles of cancer chemotherapy as well as the pharmacology of…
