Chapter Outline Erythrocyte cytochemistry 312 Siderocytes and sideroblasts 312 Haemoglobin derivatives 315 Leucocyte cytochemistry 317 Myeloperoxidase 318 Sudan Black B 319 Neutrophil alkaline phosphatase 319 Acid phosphatase reaction, including tartrate-resistant…
Chapter Outline Components of normal haemostasis 367 The blood vessel 367 Platelets 368 Blood coagulation 369 Inhibitors of coagulation 372 The fibrinolytic system 372 General approach to investigation of haemostasis…
Chapter Outline Technology and automation in blood transfusion laboratories 472 Pretransfusion compatibility systems 473 Documentation of the transfusion process 474 Blood samples and their storage requirements 474 Quality assurance in…
Chapter Outline Erythrocytes 439 Red cell antigens 439 Clinical significance of red cell alloantibodies 447 Mechanisms of immune destruction of red cells 448 Antigen–antibody reactions 450 General points of serological…
Chapter Outline Standardisation 533 Reference preparations and control materials 535 Haemoglobin reference preparations 535 Quality control preparations 536 Quality assurance procedures 536 Internal quality control procedures 537 Control charts 537…
Chapter Outline Introduction: types of laboratories 547 Organisation of clinical laboratory services 547 Level 1: primary and subdistrict laboratories 548 Level 2: intermediate (district) level laboratories 548 Level 3: regional…
Chapter Outline Common presentations of haematological diseases 497 Initial screening tests 497 Quantitative abnormalities of blood cells 498 Qualitative abnormalities of blood cells 502 Specific tests for common haematological disorders…
Chapter Outline Principles of flow cytometric immunophenotyping 330 Multicolour flow cytometric immunophenotyping 331 Methods 332 Detection of membrane antigens 333 Detection of surface immunoglobulin 334 Detection of intracellular antigens 335…
Chapter Outline Oral anticoagulant treatment using vitamin K antagonists 426 Standardisation of oral anticoagulant treatment 426 Calibration of thromboplastins 426 Local calibration of thromboplastins and direct INR determination 428 Determination…
Chapter Outline The haemoglobin molecule 283 Structural variants of haemoglobin 284 Haemoglobins with reduced solubility 284 Unstable haemoglobins 285 Haemoglobins with altered oxygen affinity 285 Haemoglobin M 285 Thalassaemia syndromes…
