Drug Drug specificity Cut-offs used in trialsa Unless stated, these represent % tumour cells stained: cell membrane staining PD-L1 immunohistochemistry primary antibody clone Complementary or companion diagnostic test Staining platform…
Inhibitor Study design Response rate Median PFS (months) Median OS (months) Reference Crizotinib Phase 1 57% Not reached n/a Kwak et al. [5] Crizotinib Phase 1 60.8% 9.7 Not reached…
Fig. 6.1 Tissue processing and tumor characteristics involved in specimen adequacy assessment. Tissue processing fixatives and decalcification methods that are suitable for molecular testing are designated with a green check,…
© Springer International Publishing AG 2018Philip T. Cagle, Timothy Craig Allen, Mary Beth Beasley, Lucian R. Chirieac, Sanja Dacic, Alain C. Borczuk, Keith M. Kerr, Lynette M. Sholl, Bryce Portier and Eric H. Bernicker (eds.)Precision Molecular Pathology of Lung CancerMolecular Pathology Libraryhttps://doi.org/10.1007/978-3-319-62941-4_21…
© Springer International Publishing AG 2018Philip T. Cagle, Timothy Craig Allen, Mary Beth Beasley, Lucian R. Chirieac, Sanja Dacic, Alain C. Borczuk, Keith M. Kerr, Lynette M. Sholl, Bryce Portier and Eric H. Bernicker (eds.)Precision Molecular Pathology of Lung CancerMolecular Pathology Libraryhttps://doi.org/10.1007/978-3-319-62941-4_19…
© Springer International Publishing AG 2018Philip T. Cagle, Timothy Craig Allen, Mary Beth Beasley, Lucian R. Chirieac, Sanja Dacic, Alain C. Borczuk, Keith M. Kerr, Lynette M. Sholl, Bryce Portier and Eric H. Bernicker (eds.)Precision Molecular Pathology of Lung CancerMolecular Pathology Libraryhttps://doi.org/10.1007/978-3-319-62941-4_18…
Fig. 15.1 Uncommon carcinomas. (a) Sarcomatoid carcinoma , pleomorphic carcinoma type with large cell undifferentiated carcinoma (left) and spindle cell pattern on the right. (b) Sarcomatoid carcinoma, spindle cell type….
© Springer International Publishing AG 2018Philip T. Cagle, Timothy Craig Allen, Mary Beth Beasley, Lucian R. Chirieac, Sanja Dacic, Alain C. Borczuk, Keith M. Kerr, Lynette M. Sholl, Bryce Portier and Eric H. Bernicker (eds.)Precision Molecular Pathology of Lung CancerMolecular Pathology Libraryhttps://doi.org/10.1007/978-3-319-62941-4_14…
© Springer International Publishing AG 2018Philip T. Cagle, Timothy Craig Allen, Mary Beth Beasley, Lucian R. Chirieac, Sanja Dacic, Alain C. Borczuk, Keith M. Kerr, Lynette M. Sholl, Bryce Portier and Eric H. Bernicker (eds.)Precision Molecular Pathology of Lung CancerMolecular Pathology Libraryhttps://doi.org/10.1007/978-3-319-62941-4_13…
Fig. 10.1 Correlation of EGFR mutations and predicted TKI response Next-Generation Sequencing (NGS) Background The clinical use of NGS has significant benefits for diagnostic biomarker discovery and clinical screening capacity compared…
