The Etiology of Acute Leukemia
Fig. 14.1 The two-hit model of acute leukemogenesis. This model hypothesizes that AML and ALL are the consequence of a combination of at least two broad classes of mutations. Class…
Psychological Aspects of Hematological Neoplasms
Cognitive Evaluation of the danger versus one’s coping resources. Focus is on the perceived threat while extraneous detail environmental details are blocked out (tunnel vision). For example, a patient may…
Immunobiology of Acute Leukemia
Earliest definition Current definition ECOG’s new definition Myeloid Myeloid Myeloid HLA-DR NEG HLA-DR NEG HLA-DRNEG CD34 HLA CD34 NEG CD11a NEG CD15 NEG CD18NEG CH15s POS CD133 NEG CD9 POS…
Epidemiology of Multiple Myeloma
Fig. 28.1 US myeloma mortality rates (age-adjusted, 2000 U.S. standard) by race and sex, 1953–1957 to 2003–2006 Rates specific for blacks, available since the early 1970s, are higher than rates…
Diagnosis and Treatment of Multiple Myeloma
Disorder Disease definition References Monoclonal gammopathy of undetermined significance (MGUS) All 3 criteria must be met: •Serum monoclonal protein <3 g/dL •Clonal bone marrow plasma cells <10 %, and •Absence…
Cytogenetics of Acute Leukemia
AML with t(8;21)(q22;q22)/RUNX1-RUNX1T1 (AML1-ETO) AML with inv(16)(p13.1q22) or t(16;16)(p13.1q22)/CBFB-MYH11 APL with t(15;17)(q22;q21)/PML-RARA AML with t(9;11)(p22;q23)/MLLT3 -MLL (specify other 11q23/MLL abnormality) AML with t(6;9)(p23;q34)/DEK-NUP214(CAN)a AML with inv(3)(q21q26.2) or t(3;3)(q21;q26.2)/RPN1-MECOM a AML…
Non-Hodgkin Lymphoma of Childhood
Syndrome Tumor Risk (%) Percent of malignancies that equal NHL Ataxia-telangiectasia Leukemia, NHL, HL, adenocarcinoma >12 41–66 Common variable ID NHL, gastric carcinoma 8–10 45–62 Severe combined ID NHL, HL,…
Platelet and Granulocyte Transfusion
Method Total white blood cells Platelets × 1011 References Mechanical apheresis Cobe spectra V5-LRS <1 × 106 2.56–7.41 [15] Fenwal amicus <1 × 106 2.82–7.14 [15] Cobe V7 turbo <1…
Cytogenetics of Lymphomas
Fig. 44.1 Partial karyotypes of chromosome abnormalities observed in lymphoid malignancies. The abnormal chromosomes are situated on the right side of each pair with the normal homologue on the left….
History of Multiple Myeloma
Fig. 26.1 Plasma cells obtained at the autopsy of Thomas Alexander McBean, January 1846 (wood engravings made from drawings by Mr. Dalrymple) (Reprinted with permission from Dalrymple J. On the…
