JAK1/2 inhibitor therapy has potential to improve the pre-HCT performance status by effective control of MF-related symptom burdenSeveral transplant studies have shown the relationship with, or better performance status with,…
Figure 14.1 The spectrum of bone marrow failure disorders and other myeloid neoplasms. AML, acute myeloid leukemia; CML, chronic myeloid leukemia; MPN, myeloproliferative neoplasm; CMML, chronic myelomonocytic leukemia; MDS, myelodysplastic…
Figure 16.1 Diagnostic algorithm for pediatric thrombocytosis. TIBC, total iron-binding capacity; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; CBC, complete blood count; MPN, myeloproliferative neoplasm; CML, chronic myeloid leukemia. Secondary…
Figure 21.1 Clinical and pathogenetic changes occurring during myeloproliferative disorder progression. MPN, myeloproliferative neoplasm; MPN-BP, MPN blast phase; ET, essential thrombocythemia; PMF, primary myelofibrosis; PV, polcythemia vera; MF, myelofibrosis; LDH,…
Figure 20.1 Pedigree of family with myeloproliferative neoplasm. Filled symbols indicate affected individuals. The Roman numerals represent generation and the Greek numeral stands for the individual family member. PV, polycythemia…
Figure 10.1 Survival estimates from diagnosis of primary myelofibrosis patients who become intermediate-2 and high-risk International Prognostic Score System (IPSS) with a blast cell count <10% at any time of…
Figure 19.1 Challenging thrombosis scenarios. MPN, myeloproliferative neoplasm; APC, activated protein C resistance. As reviewed in: Falanga A, Marchetti M. Thrombosis in myeloproliferative neoplasms. Semin Thromb Hemost. 2014;40(3):348–58. Adapted from:…
html xmlns=”http://www.w3.org/1999/xhtml” xmlns:mml=”http://www.w3.org/1998/Math/MathML” xmlns:epub=”http://www.idpf.org/2007/ops”> 18 Managing acute vascular events in patients with myeloproliferative neoplasms David A. Garcia and Bethany T. Samuelson Case 1 A 62-year-old man is referred to hematology…
Figure 17.1 Local management protocol. FBC, full blood count; BP, blood pressure; PV, polycythemia vera. There are no controlled studies regarding pregnancy outcome. As such there are no validated predictors…
+8, –7/7q–, –5/5q–, i17q, 12p–, 11q23 rearr.+1 point each1 point each (Hb: 2 points)DIPSS int-1: 1 pointDIPSS int-2: 2 pointsDIPPS high: 3 pointsPlatelets < 100 × 109/L, unfavorable karyotype, transfusion…
