Multiple Endocrine Neoplasia Type 1

Jan 16, 2017 by in ENDOCRINOLOGY Comments Off on Multiple Endocrine Neoplasia Type 1

FIGURE 150-1. Schematic representation of the distribution of 384 multiple endocrine neoplasia type 1 (MEN1) tumors in 220 patients with MEN1. The proportions of patients in whom parathyroid, pancreatic, or…

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Diabetic Nephropathy

Jan 16, 2017 by in ENDOCRINOLOGY Comments Off on Diabetic Nephropathy

FIGURE 54-1. Electron microscopic photomicrographs. A, Normal glomerular basement membrane (GBM) on the left compared to thickened GBM from a proteinuric type 1 diabetic patient on the right. B, Normal…

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Biosynthesis, Processing, and Secretion of the Islet Hormones: Insulin, Islet Amyloid Polypeptide (Amylin), Glucagon, Somatostatin, and Pancreatic Polypeptide

Jan 16, 2017 by in ENDOCRINOLOGY Comments Off on Biosynthesis, Processing, and Secretion of the Islet Hormones: Insulin, Islet Amyloid Polypeptide (Amylin), Glucagon, Somatostatin, and Pancreatic Polypeptide

FIGURE 32-1 Amino acid sequence of human and hagfish insulins, with substitutions occurring at each position in 70 other known vertebrate insulins shown below for comparison. Invariant residues are enclosed…

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Management of Diabetes Mellitus in Children

Jan 16, 2017 by in ENDOCRINOLOGY Comments Off on Management of Diabetes Mellitus in Children

Management of young children with diabetes, especially those younger than 5 years old, must balance opposing risks of hypoglycemia (see section on Hypoglycemia below) and future vascular complications. The relative…

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