FIGURE 37-1. Obesity and adipocyte hypertrophy. Adipocyte hypertrophy is a key feature of the insulin-resistant state. The flux of free fatty acids out of adipose tissue is disordered in obesity,…
FIGURE 113-1. Effects of gravity on arterial and venous blood pressures in an erect, motionless man. Arterial and venous pressures in the lower part of the body are increased, and…
FIGURE 150-1. Schematic representation of the distribution of 384 multiple endocrine neoplasia type 1 (MEN1) tumors in 220 patients with MEN1. The proportions of patients in whom parathyroid, pancreatic, or…
FIGURE 54-1. Electron microscopic photomicrographs. A, Normal glomerular basement membrane (GBM) on the left compared to thickened GBM from a proteinuric type 1 diabetic patient on the right. B, Normal…
FIGURE 119-1. The three stages of normal sexual differentiation. 1, Chromosomal sex is determined by the sex chromosome (X or Y) present in the spermatozoon at fertilization. 2, Gonadal sex…
FIGURE 93-1. Estimated proportional carriage of thyroxine (T4) on the three major plasma binding proteins is shown for euthyroid subjects with normal or variant T4 binding proteins. In the face…
FIGURE 120-1. Timeline of changes in the reproductive axis. As puberty progresses, there is little change in the frequency of LH pulsations. However, the mass of hormone secreted during each…
FIGURE 32-1 Amino acid sequence of human and hagfish insulins, with substitutions occurring at each position in 70 other known vertebrate insulins shown below for comparison. Invariant residues are enclosed…
Hypervitaminosis can occur when pharmaceutical vitamin D is taken in excess, with a wide variety of symptoms and signs related to hypercalciuria, hypercalcemia, and metastatic calcifications (Table 58-2). The toxic…
Management of young children with diabetes, especially those younger than 5 years old, must balance opposing risks of hypoglycemia (see section on Hypoglycemia below) and future vascular complications. The relative…
