Magnetic Nanostructures (MNS) for Cancer
Fig. 1 Size scale of MNS as compared to biomolecules. MNS can be adapted to include biomolecules, drugs, or targeting and imaging molecules to form targeted MNS theranostic agents Typically, MNS…
the Nanoparticle-Protein Interface for Cancer Therapeutics
Forces Strength Range (nm)* Specificity Main factors vdw forces Weak 0–10 No Interface complementarity H-bond Moderate <0 Partial Hydrogen donor/acceptor at interface Electrostatic forces Moderate 0–10 No Charge state, ionic…
as Probes for Cancer Diagnostics
Fig. 1 Structure of a spherical nucleic acid (SNA)—gold nanoparticle conjugate. (Reproduced with permission from [8]) 2.1 Synthesis of SNAs We will first describe how these constructs are synthesized. SNAs can…
the Tumor Microenvironment with Nanoparticles
Fig. 1 Schematic illustration of the major cellular and noncellular components of the tumor microenvironment (TME). The EPR effect facilitates nanoparticle (NP) accumulation. However, high interstitial fluidic pressure (IFP), pericyte coverage,…
Applications of Spherical Nucleic Acids
Fig. 1 Different mechanisms of intracellular action of antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs). a Mechanism of action for ASOs, which bind complementary mRNA and cause inhibition of translation…
Nanoparticles for Cancer Imaging and Therapy
Fig. 1 a Surfactant-free synthesis of NMOFs [27]. b, c Representative SEM images of NMOFs synthesized by nanoprecipitation (b) [48] and solvothermal method (c) [31]. Reprinted with permission from [27]. Copyright…
Chemotherapy and Imaging
Fig. 1 a–d Nanodiamond surfaces possess versatile chemical–physical properties that can mediate potent drug binding and marked improvements in MRI contrast efficiency levels. Reprinted with permission from Nature Publishing Group Furthermore,…
Nanotherapeutics in Clinical Trials
Phase Year initiated Description Cancer indication ClinicalTrials.gov identifier 0 2014 Silica imaging nanoparticle Head and neck, melanoma, prostate, cervical, uterine NCT02106598 0 2014 Magnetic nanoparticle thermoablation Prostate NCT02033447 0 2013…
and Nanoparticles
Fig. 1 Schematic drawing of radiocatalysis by nanoparticles. Exposure of nanoparticles to ionizing radiation (e.g. X-rays) causes Compton and Photoelectric effects—photoelectrons and Auger electrons (e−) are ejected from the nanoparticles as…
Cancer Nanotherapeutics
Fig. 1 Illustration of the EPR effect depicting the discontinuous epithelium lining blood vessel walls of a tumor with concurrent poor lymphatic drainage compared to normal tissue. Nanoparticles can passively accumulate…
