Thrombocytopenia: Pathophysiology and Classification George M. Rodgers PATHOPHYSIOLOGY Thrombocytopenia may be defined as a subnormal number of platelets in the circulating blood. It is the most common cause of abnormal…
Diagnostic Approach to the Bleeding Disorders George M. Rodgers Christopher M. Lehman Except for that which occurs during menstruation, spontaneous bleeding is abnormal. Surprisingly, little blood is lost, even after…
Erythrocytosis Robert T. Means, Jr. DEFINITIONS AND TERMINOLOGY The terms polycythemia and erythrocytosis are often used as if they are interchangeable; in fact, they describe related but distinct findings that…
Anemias Unique to the Fetus and Neonate Robert D. Christensen Robin K. Ohls INTRODUCTION The reference ranges used to define normal hematocrit, hemoglobin, erythrocyte count, and the erythrocyte indices, change…
Anemias During Pregnancy and The Postpartum Period Robert T. Means, Jr. OVERVIEW/EPIDEMIOLOGY By the second trimester of pregnancy, at least a mild degree of maternal anemia (defined as a hemoglobin…
Anemias Secondary to Chronic Disease and Systemic Disorders Robert T. Means, Jr. ANEMIA OF CHRONIC DISEASE The anemia that is often observed in patients with infectious, inflammatory, or neoplastic diseases…
Congenital Dyserythropoietic Anemias Gary Kupfer Linette Bosques Bertil Glader The congenital dyserythropoietic anemias (CDAs) are a heterogeneous group of inherited blood disorders characterized by anemia and morphologic abnormalities of erythroid…
Red Cell Aplasia: Acquired and Congenital Disorders Jeffrey M. Lipton Bertil Glader Robert T. Means, Jr. ACQUIRED RED CELL APLASIA Pure red cell aplasia (PRCA) is an acquired syndrome characterized…
Inherited Aplastic Anemia Syndromes Akiko Shimamura Blanche P. Alter The inherited bone marrow failure syndromes may primarily affect a single or multiple hematopoietic lineages. Four inherited bone marrow failure syndromes…
Acquired Aplastic Anemia Robert A. Brodsky HISTORICAL BACKGROUND The earliest case description of aplastic anemia was by Dr. Paul Ehrlich in 1888.1 He described a young woman who died following…
