Head and Neck
Late effect Radiotherapy dose Type of systemic therapy Bone and muscle Hypoplasia RT dose >18–24 Gy (lower dose for younger children, lower for soft tissue/muscle compared to bone) [30, 37,…
The Thyroid Gland
Fig. 9.1 Gross anatomy of the neck showing the thyroid gland in relation to nerves, vasculature, and muscles [81] The thyroid gland consists of follicles, lined with a single layer…
Pediatric Growth and Development: Impact on Vulnerability to Normal Tissue Damage from Cancer Therapy
Fig. 3.1 Four classic growth curves according to age and organ size (Modified with permission from Tanner [26]) Table 3.1 Anatomy and physiology: relative rate of development Age 0–5…
Health Promotion
Children and adolescents Improved cardiopulmonary and muscular fitness Improved bone health Improved cardiovascular and metabolic health biomarkers Reduced symptoms of depression Adults Lower risk of early death Lower risk of…
The Testes
(1) Cancer Survivorship, Childern’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylania, Philadelphia, USA 14.1 Pathophysiology 14.1.1 Overview of Normal Gonadal Development 14.1.2 Anatomy of…
Genitourinary
Organ Surgery Radiation therapy Chemotherapy Kidney Late proteinuria possible with single kidney Renal failure if bilateral A single normal kidney usually provides good function Bilateral injury can lead to renal…
Legal Issues
(1) Rutgers School of Law, 123 Washington Street, Newark, NJ, USA 21.1 Introduction 21.2 The Scope of Cancer-Based Employment Problems 21.2.1 The Types of Employment Problems Encountered by Cancer…
Methodology Considerations in the Study of Survivors of Childhood Cancer
© Springer International Publishing 2015Cindy L. Schwartz, Wendy L. Hobbie, Louis S. Constine and Kathleen S. Ruccione (eds.)Survivors of Childhood and Adolescent CancerPediatric Oncology10.1007/978-3-319-16435-9_22 22. Methodology Considerations in the Study of Survivors of Childhood Cancer Ann C. Mertens3 , Wendy Leisenring1…
Psychological Aspects of Long-Term Survivorship
Group Health belief pattern Appropriate intervention Adaptive beliefs group AYAs demonstrate high scores on all HCBI factors Support that reinforces positive beliefs and reinforces adherence to recommendations and achieving personal…
Second Malignancies Following Treatment for Childhood Cancer
Fig. 19.1 Cumulative incidence of second neoplasms after initial cancer diagnosis (Friedman et al. [3]) Unique associations with specific therapeutic exposures have resulted in the classification of SMNs into two…
