Fig. 26.1 Schematic mechanism of two immunohistochemistry methods. Top: secondary antibodies and enzymes link to polymer molecule. Bottom: biotinylated secondary antibody and labeled streptavidine Immunohistochemistry has wide application including research…
Fig. 17.1 Heritability of cancers in different sites based on the information available from twin studies 17.3 Immune Polymorphism The role of immune system in defense against malignancies was proposed…
Fig. 24.1 Intact immunoglobulin and common antibody fragments. (a) Schematic representation of an intact immunoglobulin molecule. Each heavy chain (blue) consists of three constant domains (CH1-3) and the variable domain…
Fig. 23.1 Sketch of an advanced systems biology workflow Step 1. In clinical cohorts of, for example, cancer patients vs. healthy individuals, high-throughput data of tissue and/or plasma concentrations for…
Fig. 8.1 Fine modulation of cellular recruitment by chemokines. The chemokine network is organized around several levels of complexity. (a) Most of the cell types (1, 2, 3) express several…
Fig. 12.1 Cancer immunoediting process with its three Es of elimination, equilibrium, and escape. Please note that although in many cases the sequence is followed, in others one or the…
Fig. 4.1 Anti-CD40 mAb augmented antitumor responses of anti-CD3-activated TDLN cells via ligation to CD40 on both B cells and DCs. (a) Activated total unfractionated (Unfrac) TDLN cells were co-cultured…
Fig. 25.1 (a) Manual and automated identification of antigen-specific MHC class I multimer-positive CD8+ T lymphocytes among PBMC of a HLA-A2+ healthy donor. Top panel shows a manual gating strategy…
Fig. 13.1 Functional classification of cell death modalities as described by the Nomenclature Committee on Cell Death (NCCD) [19] 13.2 Mechanisms of Apoptosis The term “apoptosis” was introduced by Kerr…
Fig. 9.1 CD95: mRNA to protein Once docked on CD95-DD, FADD self-associates [71] and binds procaspases-8 and procaspases-10, which are auto-processed and released in the cytosol as active caspases, which…
