Preexisting Lung Disease and Lung Cancer
Preexisting Lung Disease and Lung Cancer Keith M. Kerr Elsewhere in this book are reviews of the three preinvasive lung diseases that are recognized in the WHO classification of lung…
Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia
Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia Keith M. Kerr Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is described in the WHO classification of lung tumors as a generalized proliferation of…
Lung Cancer Stem Cells
Lung Cancer Stem Cells Timothy Craig Allen Although lung stem cells and the hypothesis of lung cancer stem cells do not fit the typical paradigm of preneoplastic and preinvasive lesions,…
Atypical Adenomatous Hyperplasia
Atypical Adenomatous Hyperplasia Keith M. Kerr This chapter considers the current theories of adenocarcinogenesis in the human lung and the place that atypical adenomatous hyperplasia (AAH) has in this process….
Bronchial Squamous Dysplasia and Carcinoma In Situ
Bronchial Squamous Dysplasia and Carcinoma In Situ Keith M. Kerr This chapter will review squamous dysplasia and carcinoma in situ (SD/CIS), recognized in the WHO classification of lung tumors as…
New Staging System for Lung Cancer
New Staging System for Lung Cancer Philip T. Cagle THE NEW TNM STAGING SYSTEM FOR LUNG CANCER As noted in the previous chapter, the TNM staging system for lung cancer,…
Problems in the Staging of Lung Cancer
Problems in the Staging of Lung Cancer Philip T. Cagle THE TNM STAGING SYSTEM The stage, or anatomic extent, of a cancer at the time of diagnosis is one of…
Molecular Prognostic Markers of Lung Cancer
Molecular Prognostic Markers of Lung Cancer Sanja Dacic Many studies have examined potentially prognostic genetic changes in lung carcinoma using different methodologies from immunohistochemistry to gene expression profiling. However, no…
Molecular Targeted Therapy of Lung Cancer
Molecular Targeted Therapy of Lung Cancer Sanja Dacic The most frequently targeted pathways in non-small cell lung carcinomas (NSCLC) have involved the epidermal growth factor receptor (EGFR), vascular endothelial growth…
Molecular Diagnostics of Lung Cancer
Molecular Diagnostics of Lung Cancer Sanja Dacic The diagnosis of lung carcinoma is largely based on morphology. Ancillary tools such as histochemical stains and immunohistochemistry are used in occasional cases….
