Fig. 13.1 Principle of array comparative genome hybridization (aCGH) Prominent African-Americans aberrations were chromosome X amplification in men and deletions in chromosomes 4, 8, and 18. In African-Americans several CAN…

Fig. 1.1 Illustration of the different molecular processes involved in epigenetic mechanisms. (From Qiu 2006; with kind permission of the publisher) . In mammals, DNA methylation stably alters the gene…

Fig 6.1 Location of ATM gene on long arm of chromosome 11 ATM gene is, bidirectionally, transcribed and there is an intergenic region spanning 520 bps within this gene which is…

Fig. 8.1 Localization of p53 gene on chromosome 17p13.2 The origins of p53 gene’s ancestors are initially seen in descendants of single cell choanoflagellates and early metazoan sea anemone. The…

Fig. 14.1 Cancer associated amino acid substitution of hSNF5 (a) Schematic representation of hSNF5 depicting the two repeats (RPT1 and RPT2) and cancer-associated amino acid substitution mutations. (b) Conservation of…

Fig. 7.1 Position of MCPH1 gene on chromosome 8p. 7.1.2 MCPH1 Protein BIRT1 (BRCT–repeat inhibitor of human telomerase reverse transcriptase expression) was reported as a repressor of TERT transcription by…

Fig. 15.1 RASSF1 chromosome location (The red line on the p arm) Buffy coat sample analysis also displayed an increased promoter hypermethylation of RASSF1A in children with thyroid carcinoma (Wong…

Epigenetically regulated miRNAs Location Cancer type Target protein References miR-1–1 & -2 20q13.33 (miR-1-1) 18q11.2 (miR-1-2) Hepatocellular carcinoma FOXP1 MET HDAC4 (Datta et al. 2008) Let-7i 12q14.1 Cholangiocytes TLR4 (O’Hara et al….

Fig. 3.1 Classes of interspersed repeats with their examples. (termini of the branches, and their taxa of origin in square brackets). For each class their copy number and contribution (%)…

Fig. 17.1 The map of cancer development . (Adopted from P. Mehdipour’s archive) Epigenetic as the result of genes/environmental interaction, through embryonic at the right time and precise direction and…