Pathology of the Head and Neck: Basic Considerations and New Concepts Elizabeth G. Demicco Bruce M. Wenig The role of the modern surgical pathologist is to identify tissue-based lesions and…
Pathogenesis and Progression of Squamous Cell Carcinoma of the Head and Neck Ryan M. Aronberg Natalia Issaeva Wendell G. Yarbrough Over the past few decades, advances in cellular and molecular…
Perspectives in Cancer of the Head and Neck Eugene N. Myers PERSPECTIVES IN HEAD AND NECK CANCER In the years which have passed since the 4th Edition of Cancer of…
Benign tumors Papillary adenoma Renal oncocytoma Metanephric adenoma Metanephric adenofibroma Malignant tumors Clear cell renal cell carcinoma Multilocular clear cell renal cell neoplasm of low malignant potential Papillary renal cell…
Symptoms or signs Skinner n = 309 (%) Gibbons n = 110 (%) Jayson N = 131 (%) Gupta N = 811 group 1 group 4 Hematuria 59 37 24 29 39 Abdominal or flank mass 45 21…
Features suggestive of hereditary RCC Family history of RCC or confirmed syndrome Bilaterality, multifocality, early age of onset Histology: non-clear cell with unusual features, e.g., papillary type II morphology with…
Toxicity Sunitinib Sorafenib Pazopanib Axitinib All grade % Grade 3/4 % All grade % Grade 3/4 % All grade % Grade 3/4 % All grade % Grade 3/4 % General…
Type Prevalence/histology Genetic alterations Pertinent molecular pathways Papillary RCC type 1 and 2 10–15 % Type 1 with small cells and little cytoplasm; basophilic Type 2 with large cells and…
Kd References PD-1:pembrolizumab 0.028 nM (Hamid [89] #114) * while Kd 28 pM, 50 % effective binding concentration of pembrolizumab was 0.1–0.3 nM PD-1:nivolumab 2.6 nM (Brahmer [81] #48)…
Fig. 6.1 Kidney cancers are a diverse group of malignancies with distinct genetic and molecular alterations and disparate histologic features (Permission granted from Elsevier) (Linehan et al.) Fig. 6.2 The…
