Psychological Issues
For most women, a diagnosis of gynecologic cancer is a crisis, and it is essential to consider a patient’s psychological and behavioral responses when managing her disease. While most patients…
ONCOLOGY
Cancer in Pregnancy
Cancer is diagnosed in 1 per 1,000 to 2,000 pregnancies, and is likely to increase with childbearing being delayed until higher maternal age in developed countries (1,2). Pregnancy does not…
Biologic, Targeted, and Immune Therapy
Cancer is caused by a series of events that include the accumulation of successive molecular lesions and alterations in the tumor microenvironment (1). Molecular lesions include overexpression, amplification, or mutations…
Tumor and Normal Tissue Response to Radiotherapy
Tumor and Normal Tissue Response to Radiotherapy Richard P. Hill and Robert G. Bristow 16.1 Introduction 16.2 Principles of Clinical Radiotherapy 16.2.1 Radiotherapy Dose 16.2.2 Radiotherapy Planning and Dose Delivery…
Methods of Molecular Analysis
Methods of Molecular Analysis Anthony M. Joshua, Paul C. Boutros, and Thomas Kislinger 2.1 Introduction 2.2 Principal Techniques for Nucleic Acid Analysis 2.2.1 Cytogenetics and Karyotyping 2.2.2 Hybridization and Nucleic…
Cancer Epidemiology
Cancer Epidemiology Gord Fehringer, Rayjean J. Hung, and Geoffrey Liu 3.1 Introduction and Terminology 3.1.1 Epidemiology: Definition and Scope 3.1.2 General Approach 3.1.3 Role of Epidemiology in Translational Medicine 3.2…
Molecular and Cellular Basis of Radiotherapy
Molecular and Cellular Basis of Radiotherapy Shane M. Harding, Richard P. Hill, and Robert G. Bristow 15.1 Introduction 15.2 Interaction of Radiation with Matter 15.2.1 Types of Radiation, Energy Deposition,…
Pharmacology of Anticancer Drugs
Pharmacology of Anticancer Drugs Eric X. Chen 18.1 General Principles of Pharmacology 18.1.1 Pharmacokinetics and Pharmacodynamics 18.1.2 Dosing of Chemotherapy in Individual Patients 18.1.3 Pharmacogenetics 18.2 Alkylating Agents 18.2.1 Nitrogen…
The Immune System and Immunotherapy
The Immune System and Immunotherapy Linh T. Nguyen, Evan F. Lind, and Pamela S. Ohashi 21.1 Introduction to the Immune System 21.2 Innate Immunity 21.2.1 Antigen Presentation 21.2.2 Maturation of…
Hormones and Cancer
Hormones and Cancer Paul S. Rennie, Eric Leblanc, and Leigh C. Murphy 20.1 Introduction 20.2 Basic Mechanisms of Hormone Action 20.2.1 Synthesis and Metabolism of Estrogens 20.2.2 Synthesis and Metabolism…
