Coumarin-Induced Skin Necrosis and Venous Limb Gangrene Theodore E. Warkentin Thrombotic events that result from coumarin administration are incongruous but well-documented complications of anticoagulant therapy. The key role of coumarin…
Hemorrhagic Complications of Anticoagulation Sam Schulman Mark A. Crowther Bleeding is the most common complication of anticoagulant therapy. The spectrum is from seemingly harmless subcutaneous ecchymoses, albeit cosmetically disturbing for…
Vitamin K Antagonists: Biochemistry, Pharmacology, and Management Nirmish Shah Thomas L. Ortel Sam Schulman INTRODUCTION/HISTORY Vitamin K antagonists (VKAs) are currently the most common oral anticoagulants used worldwide. The discovery…
Pharmacology and Mode of Action of Heparin and Glycosaminoglycans Meyer Michel Samama Jeanine M. Walenga Evi Kalodiki Jawed Fareed Heparin belongs to a class of linear acidic polysaccharides known as…
Overview of Therapeutic Agents Used in Thrombotic Disorders Sam Schulman Victor J. Marder In this section, the many recent developments in drug and device therapy for venous or arterial thromboembolism…
Thrombotic and Hemorrhagic Complications Associated With Stem Cell Transplantation Yona Nadir Benjamin Brenner Thrombotic and hemorrhagic complications are common in stem cell transplantation (SCT) recipients. Endothelial cell (EC) injury is…
Myeloproliferative Neoplasms and Thrombohemorrhagic Complications Ayalew Tefferi The term “myeloproliferative disorder” (MPD) was first introduced by Dameshek1 in 1951 to emphasize the clinicopathologic interrelationship between essential thrombocythemia (ET), polycythemia vera…
The Antiphospholipid Syndrome Jacob H. Rand Lucia R. Wolgast HISTORICAL BACKGROUND The antiphospholipid syndrome (APS) is an autoimmune thrombophilic condition that is defined by a constellation of clinical and laboratory…
Vasculitides James R. Stone John H. Stone The vasculitides comprise a heterogeneous group of disorders characterized by inflammation that targets and damages blood vessels. Vasculitis may be caused by infection…
The Thrombotic Thrombocytopenic Purpura and Hemolytic Uremic Syndromes James N. George Thrombotic thrombocytopenic purpura (TTP)1,2 and the hemolytic uremic syndrome (HUS)3,4 were described initially as distinct disorders. Although they may…
