Heparin-Induced Thrombocytopenia Theodore E. Warkentin Andreas Greinacher Heparin-induced thrombocytopenia (HIT) is an immune-mediated adverse drug reaction caused by heparin-dependent, platelet-activating immunoglobulin (Ig) G antibodies that recognize complexes of platelet factor…
Venous Thromboembolism During Pregnancy and With Hormonal Contraceptives Saskia Middeldorp Mathilde Nijkeuter Michiel Coppens PART I: PREGNANCY-RELATED VENOUS THROMBOEMBOLISM Epidemiology Venous thromboembolism (VTE) complicates 1 to 2 per 1,000 pregnancies.1,…
Overview of Special Clinical Groups Victor J. Marder Joel S. Bennett The majority of this textbook is devoted to basic aspects of hemostasis and thrombosis and specific hemostatic and thrombotic…
Mechanical Devices and Embolectomy HervÉ Decousus Patrick Mismetti Nicolas Meneveau VENA CAVA FILTERS AND VENOUS THROMBOEMBOLISM Interruption of the vena cava by filter insertion was initially suggested by Armand Trousseau…
Anticoagulant and Procoagulant Proteins in the Animal Kingdom Angelina Wei Ling Tan Shiyang Kwong R. Manjunatha Kini Blood circulation has a crucial role in the survival of vertebrate animals, including…
Foundations of Thrombolytic Therapy Victor J. Marder Daphne B. Stewart Thrombolytic therapy represents a conjoint approach to vascular reperfusion, based primarily on the use of fibrinolytic agents delivered systemically or…
Antiplatelet Therapy Carlo Patrono As reviewed in other chapters, platelet activation and aggregation play a key role in atherothrombosis.1 Antiplatelet drugs target enzymes or receptors involved in the platelet synthesis…
New Antithrombotic Drugs Jeffrey I. Weitz Peter L. Gross Currently available antithrombotic drugs include (a) antiplatelet agents, which inhibit platelet activation or aggregation, (b) anticoagulants, which attenuate fibrin formation, and…
Coumarin-Induced Skin Necrosis and Venous Limb Gangrene Theodore E. Warkentin Thrombotic events that result from coumarin administration are incongruous but well-documented complications of anticoagulant therapy. The key role of coumarin…
Hemorrhagic Complications of Anticoagulation Sam Schulman Mark A. Crowther Bleeding is the most common complication of anticoagulant therapy. The spectrum is from seemingly harmless subcutaneous ecchymoses, albeit cosmetically disturbing for…
