Vitamin K Antagonists: Biochemistry, Pharmacology, and Management Nirmish Shah Thomas L. Ortel Sam Schulman INTRODUCTION/HISTORY Vitamin K antagonists (VKAs) are currently the most common oral anticoagulants used worldwide. The discovery…
Pharmacology and Mode of Action of Heparin and Glycosaminoglycans Meyer Michel Samama Jeanine M. Walenga Evi Kalodiki Jawed Fareed Heparin belongs to a class of linear acidic polysaccharides known as…
Overview of Therapeutic Agents Used in Thrombotic Disorders Sam Schulman Victor J. Marder In this section, the many recent developments in drug and device therapy for venous or arterial thromboembolism…
Thrombotic and Hemorrhagic Complications Associated With Stem Cell Transplantation Yona Nadir Benjamin Brenner Thrombotic and hemorrhagic complications are common in stem cell transplantation (SCT) recipients. Endothelial cell (EC) injury is…
Myeloproliferative Neoplasms and Thrombohemorrhagic Complications Ayalew Tefferi The term “myeloproliferative disorder” (MPD) was first introduced by Dameshek1 in 1951 to emphasize the clinicopathologic interrelationship between essential thrombocythemia (ET), polycythemia vera…
The Antiphospholipid Syndrome Jacob H. Rand Lucia R. Wolgast HISTORICAL BACKGROUND The antiphospholipid syndrome (APS) is an autoimmune thrombophilic condition that is defined by a constellation of clinical and laboratory…
Vasculitides James R. Stone John H. Stone The vasculitides comprise a heterogeneous group of disorders characterized by inflammation that targets and damages blood vessels. Vasculitis may be caused by infection…
The Thrombotic Thrombocytopenic Purpura and Hemolytic Uremic Syndromes James N. George Thrombotic thrombocytopenic purpura (TTP)1,2 and the hemolytic uremic syndrome (HUS)3,4 were described initially as distinct disorders. Although they may…
Consumptive Thrombohemorrhagic Disorders Marcel Levi Donald I. Feinstein Robert W. Colman Victor J. Marder Known variously as disseminated intravascular coagulation (DIC), defibrination, or the consumption coagulopathies, consumptive thrombohemorrhagic disorders are…
Overview of Complex Thrombohemorrhagic Disorders Theodore E. Warkentin Victor J. Marder This overview of “complex thrombohemorrhagic disorders” emphasizes their heterogeneous clinical presentation ranging from bleeding to microvascular and macrovascular thrombosis…
