Alkylating Agents
Alkylating Agents Kenneth D. Tew PERSPECTIVES Alkylating agents were the first anticancer molecules developed, and they are still used today. After more than 50 years of use, the basic chemistry…
Pharmacogenomics
Pharmacogenomics Christine M. Walko Howard L. McLeod INTRODUCTION The evolution of understanding cancer biology has yielded many advances that have been translated into cancer treatment. Application of this knowledge has…
Pharmacokinetics and Pharmacodynamics of Anticancer Drugs
Pharmacokinetics and Pharmacodynamics of Anticancer Drugs Alex Sparreboom Sharyn D. Baker INTRODUCTION Drug selection and therapy considerations in oncology were originally solely based on observations of the effects produced.1 To…
Cancer Immunotherapy
Cancer Immunotherapy Steven A. Rosenberg Paul F. Robbins Giao Q. Phan Steven A. Feldman James N. Kochenderfer INTRODUCTION Progress in understanding basic aspects of cellular immunology and tumor-host immune interactions…
Essentials of Radiation Therapy
Essentials of Radiation Therapy Meredith A. Morgan Randall K. Ten Haken Theodore S. Lawrence INTRODUCTION The beneficial use of radiation was launched by the experiments of Wilhelm Roentgen, who, in…
Trends in United States Cancer Mortality
Trends in United States Cancer Mortality Tim E. Byers INTRODUCTION Cancer incidence registries now cover nearly all of the US population. State-based vital records systems and aggregate national systems regularly…
Epidemiologic Methods
Epidemiologic Methods Xiaomei Ma Herbert Yu INTRODUCTION Epidemiology is the study of the distribution and determinants of health-related states or events in specified populations and the application of this study…
Obesity and Physical Activity
Obesity and Physical Activity Yani Lu Jessica Clague Leslie Bernstein INTRODUCTION Evidence showing that physical activity is associated with decreased cancer risk and that obesity is associated with increased cancer…
Dietary Factors
Dietary Factors Karin B. Michels Walter C. Willett INTRODUCTION Over two decades ago, Doll and Peto1 speculated that 35% (range: 10% to 70%) of all cancer deaths in the United…
Physical Factors
Physical Factors Mats Ljungman INTRODUCTION Ionizing radiation (IR) and ultraviolet (UV) light have challenged the genetic integrity of all living organisms throughout time. By inducing DNA damage and subsequent mutations,…
