Rodent Models for the Study of Diabetes Clayton E. Mathews Edward H. Leiter Patients with diabetes share the clinical symptom of hyperglycemia accompanied by either insufficient circulating insulin or inadequate…
Alterations in Protein Metabolism in Diabetes Mellitus Craig S. Stump Sreekumaran Nair HISTORICAL PERSPECTIVE Before insulin treatment became readily available, stunted growth, cachexia, and muscle wasting were well recognized in…
Fat Metabolism in Diabetes Ananda Basu Michael D. Jensen The pathophysiology of diabetes mellitus involves impairments in insulin secretion and insulin action. Whereas type 1 diabetes results from extreme impairment…
Regulation of Hepatic Glucose Metabolism Daryl K. Granner Donald K. Scott INTRODUCTION Background Glucose provides a major energy supply for mammalian cells; however, some tissues are much more dependent than…
Biology of Skeletal Muscle Alison C. Jozsi Laurie J. Goodyear ANATOMY The human body contains more than 600 different skeletal muscles, collectively comprising the largest single organ of the body….
Biology of Adipose Tissue Sheila Collins Rexford S. Ahima Barbara B. Kahn EVOLVING CONCEPTS ABOUT ADIPOSE TISSUE PHYSIOLOGY From an evolutionary perspective, the biology of adipocytes begins with the strategies…
Magnetic Resonance Spectroscopy Studies of Liver and Muscle Glycogen Metabolism in Humans Roy Taylor Gerald I. Shulman PRINCIPLES OF MAGNETIC RESONANCE SPECTROSCOPY Although the vast majority of atoms have no…
Glucagon and Glucagon-like Peptides Joel F. Habener Timothy J. Kieffer Investigations during the past 15 years have uncovered a remarkable, unanticipated complexity in the repertoire of biologically active hormones produced…
The Molecular Mechanism of Insulin Action and the Regulation of Glucose and Lipid Metabolism C. Ronald Kahn Alan R. Saltiel More than 18 million people in the United States have…
Insulin-like Growth Factors Karen C. McCowen Robert J. Smith Insulin-like growth factors (IGFs) belong to a family of peptide hormones with structural and functional similarities to insulin. Initially identified on…
