Fat Metabolism in Diabetes
Fat Metabolism in Diabetes Ananda Basu Michael D. Jensen The pathophysiology of diabetes mellitus involves impairments in insulin secretion and insulin action. Whereas type 1 diabetes results from extreme impairment…
Regulation of Hepatic Glucose Metabolism
Regulation of Hepatic Glucose Metabolism Daryl K. Granner Donald K. Scott INTRODUCTION Background Glucose provides a major energy supply for mammalian cells; however, some tissues are much more dependent than…
Biology of Skeletal Muscle
Biology of Skeletal Muscle Alison C. Jozsi Laurie J. Goodyear ANATOMY The human body contains more than 600 different skeletal muscles, collectively comprising the largest single organ of the body….
Biology of Adipose Tissue
Biology of Adipose Tissue Sheila Collins Rexford S. Ahima Barbara B. Kahn EVOLVING CONCEPTS ABOUT ADIPOSE TISSUE PHYSIOLOGY From an evolutionary perspective, the biology of adipocytes begins with the strategies…
Magnetic Resonance Spectroscopy Studies of Liver and Muscle Glycogen Metabolism in Humans
Magnetic Resonance Spectroscopy Studies of Liver and Muscle Glycogen Metabolism in Humans Roy Taylor Gerald I. Shulman PRINCIPLES OF MAGNETIC RESONANCE SPECTROSCOPY Although the vast majority of atoms have no…
Glucagon and Glucagon-like Peptides
Glucagon and Glucagon-like Peptides Joel F. Habener Timothy J. Kieffer Investigations during the past 15 years have uncovered a remarkable, unanticipated complexity in the repertoire of biologically active hormones produced…
The Molecular Mechanism of Insulin Action and the Regulation of Glucose and Lipid Metabolism
The Molecular Mechanism of Insulin Action and the Regulation of Glucose and Lipid Metabolism C. Ronald Kahn Alan R. Saltiel More than 18 million people in the United States have…
Insulin-like Growth Factors
Insulin-like Growth Factors Karen C. McCowen Robert J. Smith Insulin-like growth factors (IGFs) belong to a family of peptide hormones with structural and functional similarities to insulin. Initially identified on…
Hormone-Fuel Interrelationships: Fed State, Starvation, and Diabetes Mellitus
Hormone-Fuel Interrelationships: Fed State, Starvation, and Diabetes Mellitus Neil B. Ruderman Martin G. Myers Jr. Stuart R. Chipkin Keith Tornheim BASIC PRINCIPLES Fuel Reservoirs Humans have a constant requirement for…
Insulin Secretion in Vivo
Insulin Secretion in Vivo Melissa K. Cavaghan Kenneth S. Polonsky The classic experiments of Von Mering and Minkowski at the turn of the last century demonstrating that pancreatectomy in dogs…
