The Birth, Life, and Death of Red Blood Cells: Erythropoiesis, The Mature Red Blood Cell, and Cell Destruction John G. Quigley Robert T. Means, Jr. Bertil Glader ERYTHROPOIESIS Concept of…
Origin and Development of Blood Cells Andrew Chow Paul S. Frenette BLOOD CELLS The blood contains several different types of cells. Each of these cell types is quite distinct in…
Molecular Diagnosis in Hematology Dan Jones INTRODUCTION Molecular diagnostics, including DNA- and RNA-based testing and genomics, play an increasingly important role in diagnosis and monitoring of patients. The tremendous explosion…
Cytogenetics Athena M. Cherry Charles D. Bangs INTRODUCTION Cytogenetics is the study of chromosome structure and function. Chromosome analysis is an integral part of diagnosing hematologic malignancies and is important…
Clinical Flow Cytometry Anna Porwit DEFINITION One of the meanings of the word flow is “to move with a continual shifting of the component particles.” The term cytometry refers to…
Examination of the Blood and Bone Marrow Kristi J. Smock Sherrie L. Perkins Careful assessment of the blood is often the first step in assessment of hematologic function and diagnosis…
The Diagnostic and Therapeutic Approach to Hematologic Problems Maxwell M. Wintrobe The study of the blood has a long history. Humankind probably always has been interested in the blood because…
Hyperthyroidism in the Neonatal Period and Childhood Stephen H. Lafranchi Cheryl E. Hanna Hyperthyroidism is less common in children and adolescents than in adults, and it is rare in neonates….
Reduced Sensitivity to Thyroid Hormone: Defects of Transport, Metabolism, and Action Alexandra M. Dumitrescu Samuel Refetoff Resistance to thyroid hormone (RTH), a syndrome of reduced responsiveness of target tissues to…
Thyroid Disruptors Elizabeth N. Pearce Introduction Over the past decades, there has been increasing concern about human and wildlife exposure to endocrine disruptors, chemicals that could disrupt endogenous hormone function….
