Randomized Clinical Trials in Melanoma
The incidence of melanoma is increasing and it is estimated that, in the United States, the lifetime risk of developing melanoma is 1 in 55. There have been many randomized…
Randomized Clinical Trials in Soft Tissue Sarcoma
Soft tissue sarcomas (STS) are rare, but potentially lethal, extraskeletal mesenchymal neoplasms. It is estimated that approximately 12,000 cases of STS are reported annually in the United States, with 3,500…
Commentary: Randomized Controlled Trials
In 2002, the fellows and staff at Memorial Sloan-Kettering put together an issue of Surgical Oncology Clinics of North America on randomized clinical trials in oncology. At that time, I…
New Frontiers in Pancreatic Cancer Research
Pancreatic adenocarcinoma (PDA) is a highly lethal and aggressive malignancy with high mortality rates. It is critical to evaluate novel therapeutic strategies and targets for the treatment of this disease….
Novel Targets for Pancreatic Cancer Therapy
Pancreatic adenocarcinoma (PDA) is one of the cancers that is resistant to most conventional anticancer therapies. PDA-affected patients show a poor prognosis. The 5-year survival rate for PDA is 5%…
Status of Neoadjuvant Therapy for Resectable Pancreatic Cancer
Neoadjuvant treatment in patients with pancreatic cancer has increased the efficiency of surgery and improved patients’ response to radiotherapy. It has also been shown to expose previously occult metastatic disease…
Update on Adjuvant Trials for Pancreatic Cancer
Adjuvant therapy for pancreatic cancer remains a controversial topic, with a paucity of randomized controlled trials in this area and various limitations in the trials that have been conducted to…
Management of Borderline Resectable Pancreatic Cancer
Borderline resectable pancreatic cancer is an emerging stage of disease defined by computed tomogrpahy criteria, patient (Katz type B), or disease characteristics (Katz type C). These patients are particularly well…
Quality Improvement for Pancreatic Cancer Care: Is Regionalization a Feasible and Effective Mechanism?
Variability exists in the quality of pancreatic cancer care provided in the United States. High-volume centers have been shown to have improved outcomes for pancreatectomy. Regionalization of pancreatic cancer care…
Laparoscopic Surgery for Pancreatic Tumors
The rapid growth of minimally invasive technology and experience in recent decades has revolutionized many aspects of oncologic surgery. Adoption of laparoscopic pancreatectomy has been slow due to the inherent…
