Palliative Care in Pediatric Oncology
Chapter Outline INTEGRATING PALLIATIVE CARE FROM THE TIME OF DIAGNOSIS Advantages of Early Integration of Palliative Care Enhancing Integration of Palliative Care When Cure is No Longer Possible MAKING THE…
Nursing Care of Patients with Childhood Cancer
Chapter Outline HISTORY OF PEDIATRIC ONCOLOGY NURSING Nursing Education and Professional Certification OVERVIEW OF THE PEDIATRIC ONCOLOGY NURSE’S ROLE The Nurse’s Relationship with Patients, Families, and Other Providers CARING FOR…
Infectious Disease in the Pediatric Cancer Patient
Chapter Outline INTRODUCTION GENERAL ISSUES RELEVANT TO INFECTIONS Risk Factors for Infection Infection Classification Intervention Approaches MAJOR PATHOGENS Bacteria Fungi Viral Infections Protozoal Infections FEVER AND NEUTROPENIA Initial Risk Stratification…
Rhabdomyosarcoma
Chapter Outline PATHOLOGIC CLASSIFICATION OF RHABDOMYOSARCOMA RHABDOMYOSARCOMA IN CANCER PREDISPOSITION SYNDROMES GENETICS OF SPORADIC RHABDOMYOSARCOMA Gene Fusions Generated by Chromosomal Rearrangements Chromosome Copy Number Changes Amplification of Specific Chromosomal Regions…
Pediatric Radiation Oncology
Chapter Outline PRINCIPLES OF RADIATION ONCOLOGY THE PHYSICAL BASIS OF RADIOTHERAPY RADIOBIOLOGY Mechanisms of Radiation Damage Clonogenic Survival Curves The Oxygen Effect Radiation Interactions with Chemotherapeutic Agents TECHNOLOGICAL ADVANCES IN…
Pediatric Myeloid Leukemia, Myelodysplasia, and Myeloproliferative Disease
Chapter Outline ACUTE MYELOGENOUS LEUKEMIA Epidemiology and Etiology Biology Molecular Genetics Morphology and Cytochemistry Immunophenotype Cytogenetics Clinical Presentation Treatment Prognosis Minimal Residual Disease Relapsed or Refractory Disease ACUTE PROMYELOCYTIC LEUKEMIA…
Retinoblastoma
Chapter Outline EPIDEMIOLOGY BIOLOGY OF RETINOBLASTOMA Cellular Origins of Retinoblastoma Retinoblastoma Tumor Cell Differentiation Retinoblastoma Genomics and Epigenomics Retinoblastoma Preclinical Models Retinoblastoma Translational Research GENETIC COUNSELING FOR FAMILIES WITH RETINOBLASTOMA…
Immunotherapy of Cancer
Chapter Outline KEY COMPONENTS OF THE IMMUNE SYSTEM AND THEIR RELEVANCE IN CANCER IMMUNOTHERAPY Humoral Arm of the Immune System Cellular Arm of the Immune System TARGET ANTIGENS IN CANCER…
Pediatric Renal Tumors
Chapter Outline PATHOLOGY OF PEDIATRIC RENAL TUMORS Staging Wilms Tumor (Nephroblastoma) Clear Cell Sarcoma of the Kidney Congenital Mesoblastic Nephroma Malignant Rhabdoid Tumor of the Kidney Renal Carcinomas in Children…
Neuroblastoma
Chapter Outline EPIDEMIOLOGY PATHOGENESIS Embryology Development of the Sympathetic Nervous System Genetic Disorders Associated with Neuroblastoma Neuroblastoma Stem Cells Hereditary Predisposition to Neuroblastoma Genetic Aberrations in Sporadic Neuroblastoma Chromosomal Abnormalities…
